To observe the effect of mangiferin on nervous system,cardiovascular system and respiratory system,and analyze its general pharmacological effect.Thus providing reference for subsequent toxicological test.Methods:The mice were intragastric administered magiferin of 0.24,1.0 and 3.0 g/kg·bw/ Then changes in its general behavior,posture,gait,salivation,sweating,bruising,and convulsions were recorded.The effects of pentobarbital sodium on mice's sleep were measured.Also,beagle dogs were given mangiferin by duodenum in the dose of 0.1,0.7,4.0 g/kg·bw.Changes in electrocardiogram,blood pressure,and respiratory were recorded after administration.Results:There was no significant change on the general behavior,posture,salivation,sweating,dryness,convulsions,muscle fibrillation of rats.There was no significant effect on independent activities,coordination of exercise and the sleep rate of mice on the sub-threshold sleep dose of pentobarbital sodium.Similarly,there was no significant change on dog electrocardiogram,blood pressure,and breathing.Conclusion:Under the experimental conditions,mangiferin has no significant effect on the mental and nervous system of mice or the cardiovascular system and respiratory system of dog.