To observe the differences between blood heat syndrome, blood dryness syndrome and blood stasis syndrome of psoriasis in JAK/STAT signaling pathways. Methods:A total of 18 psoriasis cases in our hospital were divided into 3 groups based on TCM syndrome differentiation. The three groups were blood heat syndrome group, blood dryness syndrome group and blood stasis syndrome group. And 6 healthy participants also participated in the trail. Their general information was recorded. RT-PCR was employed to test the difference of IL-22R1, JAK1, STAT3 and c-myc in participants' skin tissue samples. Results:The gene transcription correlation test among 24 psoriasis patients show that IL-22R1, JAK1, STAT3 and c-myc were all positively correlated to each other (P<0.05 or P<0.01）. The gene transcriptions of IL-22R1, JAK1, STAT3 and c-myc in blood heat group were significantly higher than healthy case group (P<0.01）. In blood dryness group, gene transcription of IL-22R1, JAK1 and STAT3 were higher than healthy group (P<0.05）. Conclusion:The active status of JAK/STAT signaling pathway could be an important factor in the formation of psoriasis blood heat syndrome. While the JAK/STAT signaling pathway may result in blood heat syndrome turning into blood dryness syndrome and blood stasis syndrome.