To study the clinical efficacy of traditional Chinese medicine with chemotherapy in the treatment of non-small-cell lung cancer (NSCLC) at advanced stage in the treatment of non-small lung cancer (NSCLC) in Chinese traditional Chinese medicine, to provide references for clinical application.Methods:A total of 148 cases with advanced NSCLC treated in the hospital from February 2012 to December 2016 were selected and randomly divided into two groups. Patients in the treatment group were given elemene combined with chemotherapy, while patients in the chemotherapy group only received chemotherapy. After 3 courses of treatment, the curative effect and changes in carcinoembryonic antigen (CEA) level, quality of life and physical strength of the two groups were observed and compared.Results:The curative effect rate of the treatment group was 50.0% and the chemotherapy group was 28.38%. (χ2=7.258,P<0.05). The KPS score of the treatment group was raised from (67.05±6.80) to (73.45±5.47), and the CEA level was reduced to (13.01±2.64) mu g/L by (21.37±4.33) mu g/L; the KPS score of the chemotherapy group was raised from (67.01±7.04) to (78.58±4.89), but the CEA level was reduced by (22.18±4.50) mu g/L to (8.99±1.89) mu g/L. The scores of physical condition, social family situation, emotion, function and lung cancer symptom of the treatment group were (19.25±3.45), (18.76±2.91), (18.42±2.31), (19.33±2.34) and (24.06±3.57) respectively; those of the control group was (13.93±2.12), (14.63±3.42), (13.37±2.68), (16.27±2.85), and (19.58±3.43) (P<0.05).Conclusion:The clinical curative effect of traditional Chinese medicine, elemene, combined with chemotherapy for non-small cell lung cancer at advanced stage is good and can significantly reduce the CEA level and improve body strength and quality of life, with great efficiency.