世界中医药

目的：探讨血脂康胶囊联合阿托伐他汀治疗高脂血症的疗效及对血脂、炎性因子的影响。方法：选取2015年4月至2017年2月华中师范大学医院收治的高脂血症患者488例作为研究对象，按照随机数字表法分为观察组和对照组，每组244例。2组均给予阿托伐他汀治疗，观察组在此基础上联用血脂康胶囊治疗，2组均连续治疗3个月。比较2组临床治疗效果；检测并比较2组治疗前后血脂指标、炎性因子及血管内皮功能指标水平的变化；比较2组不良反应发生情况。结果：观察组临床治疗总有效率为95.49%，显著高于对照组的83.20%，差异有统计学意义（P<0.05）；与治疗前比较，治疗后2组血清TC、TG、LDL-C水平均显著下降，HDL-C水平显著升高，且观察组改善效果优于对照组，差异有统计学意义（P<0.01）；与治疗前比较，治疗后2组血清IL-6、IL-18和ET水平均显著降低，NO水平显著升高，且观察组改善效果优于对照组，差异有统计学意义（P<0.01）；观察组无明显不良反应，对照组不良反应发生率为13.93%，显著高于观察组，差异有统计学意义（P<0.05）。结论：血脂康胶囊联合阿托伐他汀能显著改善高脂血症患者血脂水平，降低炎性反应，同时也可改善患者血管内皮功能，减少患者不良反应，临床效果显著。

English Summary:

To explore the effect of Xuezhikang Capsule combined with atorvastatin in treatment of hyperlipidemia and its influence on blood lipids and inflammatory factors.Methods:A total of 488 patients with hyperlipidemia who had treatment in the hospital were selected and divided into treatment group (n＝244) and control group (n＝244) according to the random number table method. The two groups were both treated with atorvastatin while the treatment group was additionally treated with Xuezhikang Capsule. Patients in the two groups were treated continuously for 3 months. The clinical effects of the two groups were compared. The levels of blood lipids, inflammatory factors and vascular endothelial function indexes were detected and compared between the two groups before and after treatment. Adverse reactions were compared between the two groups. Results:The clinical total efficiency of the treatment group was 95.49%, which was significantly higher than 83.20% of the control group (P<0.05). The levels of serum TC, TG, LDL-C in the two groups after the treatment decreased significantly and HDL-C increased significantly. The improvement of the treatment group was better than that of the control group (P<0.01). The levels of serum IL-6, IL-18 and ET in the two groups after the treatment decreased significantly, NO increased significantly, and the improvement of the treatment group was better than that of the control group (P<0.01). There was no obvious adverse reaction in the treatment group but the adverse reaction rate of the control group was 13.93%, which was significantly higher than that in the treatment group (P<0.05). Conclusion:Xuezhikang Capsule combined with atorvastatin can significantly improve blood lipid levels and vascular endothelial function of patients with hyperlipidemia and reduce inflammatory response and adverse reaction, showing that its clinical effect is remarkable.

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