世界中医药

目的:探讨雷公藤多苷对早期糖尿病肾病患者的血管内皮功能的影响,同时观察该药对患者T淋巴细胞亚群的干预效应。方法:选取2010年1月至2016年1月漯河市第三人民医院内一科住院的早期糖尿病肾病患者80例,随机分为对照组和观察组,每组40例。2组患者均接受常规控制血糖、改善肾功能方案,观察组在常规治疗方案基础上加用雷公藤多苷,2组均接受为期12周的治疗,比较2组治疗前后血糖、血脂、肾功能指标的变化,同时检测2组患者干预前后血管内皮细胞(VEGF)、T淋巴细胞亚群百分比的变化。结果:1)治疗结束后2组患者血糖、血脂、肾功能指标均有明显改善,与对照组比较,观察组改善的幅度更明显,差异有统计学意义(P<0.05)。2)治疗后2组VEGF浓度均较治疗前明显下降,其中观察组下降的趋势更为明显(P<0.05)。3)治疗后观察组Th17/Treg细胞百分比低于对照组,Th1/Th2细胞百分比较对照组明显升高,差异均有统计学意义(P<0.05)。结论:雷公藤多苷可明显改善早期糖尿病肾病患者的血管内皮功能,同时可纠正患者T淋巴细胞亚群失衡现象。

English Summary:

To investigate the intervention effect of Tripterygium glycosides on vascular endothelial function and T lymphocyte subsets in patients with early diabetic nephropathy.Methods:Eighty cases of early diabetic nephropathy patients hospitalized in Endocrinology Department in the hospital during January 2010 to January 2016 were included and were randomly divided into the control group and the observation group, with 40 cases in each group. Patients in both the two groups accepted routine treatment scheme of diabetes control and renal function improvement, while patients in the observation group combined with Tripterygium glycosides on the basis of conventional treatment. Both the two groups were treated for 12 weeks. The changes of blood glucose, blood lipid and renal function index of the two groups before and after the treatment were compared, and changes in the percentage of vascular endothelial cells (VEGF) and T lymphocyte subsets in the two groups before and after the intervention were detected at the same time.Results:1) Blood glucose, blood lipid, renal function indexes markedly of patients in the two groups improved after the treatment. The improvement range of the observation group was more obviously, compared with the control group, with statistically significant differences (P<0.05). 2) The VEGF concentration decreased significantly in both of the two groups after the treatment; the downward trend in the observation group was more obvious (P<0.05). 3) The percentage of Th 17/Treg cells in the observe group was lower than that of the control group after the treatment, and percentage of the Th1/Th2 cells in the observe group increased significantly compared to that of the control group, which showed statistically significant differences (P<0.05).Conclusion:Tripterygium glycosides can significantly improve vascular endothelial function in patients with early diabetic nephropathy and relieve the disorder of T lymphocyte subgroup.

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