| 引用本文:张竹华，翟军鹏，戴梅，褚福永，韩垚，田伟，李腾飞，胡馨，张大炜.消心痹方对肥厚型心肌病患者心脏功能及心率变异性的影响[J].世界中医药,2017,(08):. |
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| 消心痹方对肥厚型心肌病患者心脏功能及心率变异性的影响 |
| Effects of Xiaoxinbi Formula on Left Ventricular Function and Heart Rate Variability in Patients with Hypertrophic Aardiomyopathy |
| 投稿时间：2017-03-10 |
| DOI：10.3969/j.issn.1673-7202.2017.08.030 |
| 中文关键词: 消心痹方 肥厚型心肌病 左室舒张功能 心率变异性 |
| English Keywords:Xiaoxinbi Formula Hypertrophic cardiomyopathy Left ventricular diastolic function Heart rate variability |
| 基金项目:国家自然科学基金青年基金项目(81273741） |
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| 中文摘要: |
| 目的：本研究观察消心痹方治疗肥厚型心肌病患者的疗效，评价其对患者左室舒张功能及HRV（Heart Rate Variability，HRV）的影响。方法：选取首都医科大学附属北京中医医院收治的HCM患者72例，随机分为2组，对照组35例，给予β受体阻滞剂等常规西药治疗；观察组37例，在常规治疗的基础上给予消心痹方口服，2次/d，2组疗程均为90 d，观察各组治疗前后中医症状、超声心动图指标、心率变异性及不良反应发生情况。结果：2组患者中医症状疗效比较观察组乏力、气短、心悸、水肿、胸闷、食欲不振症状总有效率显著优于对照组，差异有统计学意义(P<0.05)。2组患者治疗前后超声心动指标比较，观察组较对照组明显好转，差异有统计学意义（P<0.05）。2组治疗后NYHA心功能分级均明显降低，且观察组优于对照组，差异有统计学意义（P<0.05）。HRV各项指标在治疗后较治疗前明显升高，差异有统计学意义（P<0.05）；治疗后观察组与对照组比较，HRV各项指标有统计学意义，差异有统计学意义（P<0.05）。结论：消心痹方联合西药能够很好地改善肥厚型心肌病患者呼吸困难、乏力、水肿、气短等中医症状，改善心脏功能，其作用机制可能与改善心率变异性，抑制交感神活性有关。 |
| English Summary: |
| To observe the effects of Xiaoxinbi formula on left ventricular diastolic function and heart rate variability (HRV) in patients with hypertrophic cardiomyopathy (HCM).Methods:Seventy-two patients diagnosed with HCM were selected and randomized into two groups.The control group (35 patients) was given routine western medication, including β-blockers.The treatment group (37 patients) was given routine western medication plus Xiaoxinbi formula, twice daily.Both of the treatment lasted for 90 days.Chinese medicine symptoms, echocardiography changes, as well as HRV parameters were observed and analyzed before and after the treatment.Results:The symptoms of fatigue, breath shortness, palpitation, chest distress, and loss of appetite syndrome in the treatment group were significantly improved compared to the control group (P<0.05).Besides, the parameters of echocardiography were significantly improved compared to those of the control group after the treatment (P<0.05).Meanwhile, the NYHA levels were also significantly improved compared with those of the control group after the treatment (P<0.05).Additionally, the parameters of HRV were also significantly improved compared with those in the control group after the treatment (P<0.05).Conclusion:Xiaoxinbi formula has obvious clinical effects in improving the TCM symptoms of fatigue, breath shortness, palpitation, chest distress, and loss of appetite.It can improve left ventricular function, and the possible mechanisms may be related to HRV improvement and sympathetic activity inhibition. |
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