This paper is to introduce professor Weng Weiliang’ s experience in the treatment of hyperthyroid heart disease with refractory heart failure. Based on the clinical case, the author summarizes clinical syndrome differentiation and treatment of hyperthyroid heart disease. Professor Weng believes that heart failure due to hyperthyroid heart disease is caused by qi deficiency and blood stasis and devitalization of heart yang, which later may develop into yang deficiency and blood stasis and fluid retention stagnating in the interior. The herbal formulas should be modified on the basis of the clinical manifestations and complications. The treatment should be determined according to the severity of the root cause or symptoms. When heart yang is deficient as the main cause, medicines of tonifying qi, warming yang and activating blood should be applied. When Yang gradually recovers, crude dried ginseng should be added for tonifying heart qi to consolidate the effect. Medicines with the function of activating blood and alleviating water retention also could be added. Protecting the fluid and tonifying qi and nourishing yin should be in the priority during the whole treatment. Treatment chosen based on symptoms, syndrome and individual is important. Prescriptions are flexible and medication is safe.