世界中医药

目的：探讨柴胡桂枝汤联合西替利嗪治疗过敏性鼻炎的疗效及对炎性细胞因子的影响。方法：选取2016年3月至2017年1月重庆市江津区中心医院收治的过敏性鼻炎患者114例,按照随机数字表法分为对照组(n＝57)和观察组(n＝57),对照组采用西替利嗪治疗,观察组在对照组的基础上联合柴胡桂枝汤治疗,2组连续治疗3个月。比较2组临床治疗效果,观察比较2组临床症状消失时间,比较2组治疗前后体征及症状评分变化,检测并比较2组治疗前后炎性细胞因子水平变化。结果：观察组临床治疗总有效率为94.74%,显著高于对照组的82.46%(P<0.05);观察组流涕、鼻塞、鼻痒及喷嚏等临床症状消失时间均显著早于对照组(P<0.05或P<0.01);与治疗前比较,治疗后2组体征及症状评分均显著降低(P<0.01),且观察组低于对照组(P<0.05或P<0.01);与治疗前比较,治疗后2组γ-干扰素(IFN-γ)、白介素-10(IL-10)水平显著升高,白介素-4(IL-4)、白介素-17(IL-17)水平显著降低(P<0.05或P<0.01),且2组间差异有统计学意义(P<0.01)。结论：柴胡桂枝汤联合西替利嗪能显著改善过敏性鼻炎患者临床症状及体征,降低炎性反应,效果显著。

English Summary:

To explore the curative effect of Chaihu Guizhi Decoction combined with cetirizine in the treatment of allergic rhinitis and its influence on inflammatory cytokines.Methods:A total of 114 patients with allergic rhinitis who were admitted and treated in Jiangjin Central Hospital of Chongqing from March 2016 to January 2017 were selected and divided into the control group (n＝57) and the treatment group (n＝57) by random number table.The control group was treated with cetirizine, and the treatment group was treated with Chaihu Guizhi Decoction on the basis of the control group.Both groups were continually treated for 3 months.The clinical effects, the disappearance time of clinical symptoms, the signs and symptoms scores of 2 groups before and after treatment were compared, and the levels of inflammatory cytokines in 2 groups before and after treatment were detected and compared.Results:The total effective rate of the treatment group was 94.74%, which was significantly higher than that 82.46% of the control group (P<0.05); The disappearance time of runny nose, nasal congestion, nasal itching and sneezing and other symptoms of the treatment group was earlier than those of the control group (P<0.05 or P<0.01); Scores of signs and symptoms in 2 groups after treatment were significantly lower when compared with that before treatment (P<0.01), and the treatment group were lower than the control group (P<0.05 or P<0.01); The levels of interferon-γ (IFN-γ), interleukin-10 (IL-10) of 2 groups after treatment significantly increased, and the levels of interleukin-4 (IL-4), interleukin-17 (IL-17) significantly decreased when compared that before treatment (P<0.05 or P<0.01), and the differences between the 2 groups were significant (P<0.01).Conclusion:Chaihu Guizhi Decoction combined with cetirizine can significantly improve the clinical symptoms and signs of the patients with allergic rhinitis, and reduce the inflammatory response with remarkable effects.

查看全文查看/发表评论下载PDF阅读器