| 引用本文:周君，叶小舟，唐甜，王聪，冯哲宇，张媞，顾铭，姚昶.三黄煎剂改善乳腺癌患者手术创面炎性反应状态30例临床研究[J].世界中医药,2017,(09):. |
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| 三黄煎剂改善乳腺癌患者手术创面炎性反应状态30例临床研究 |
| A Clinical Trial of the Effects of San Huang Decoction on Inflammatory Response of Surgical Wound in Patients with Breast Cancer |
| 投稿时间：2016-08-14 |
| DOI：10.3969/j.issn.1673-7202.2017.09.022 |
| 中文关键词: 乳腺癌；三黄煎剂 围手术期；创面；炎性反应状态 |
| English Keywords:SHD Breast Cancer Surgery Inflammatory Response Wound Traditional Chinese Medicine |
| 基金项目:江苏省中医院高峰学术人才培养(y2014cr06）；2015年中韩合作项目(313） |
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| 中文摘要: |
| 目的：观察三黄煎剂改善乳腺癌围手术期患者创面炎性反应临床功效，探讨其促进患者恢复与改善乳腺癌预后的作用。方法：将30例乳腺癌患者随机分为观察组与对照组，每组病例数各15例。对照组予以基础治疗，实验组在基础治疗同时于术前1 d起至术后第7天，每天口服三黄煎剂一剂，分早晚各服1次，2组分别于手术当天、术后第1天、第3天、第7天评估中医症状与炎性反应症状积分及腋窝引流量、ELISA法测定腋窝引流液相关指标白介素-2（IL-2）、白介素-6（IL-6）、白介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、C-反应蛋白（CRP）水平。结果：观察组对中医症状积分与炎性反应积分于术后第3天显著改善，与对照组比较，有统计学意义（P<0.05），腋窝引流量显著减少，引流液中炎性反应指标术后第1天均显著上升，观察组术后第3天即显著下降，第7天CRP、IL-6、IL-2R含量恢复至术前水平，术后7天对照组仍显著高于术前，术后第3天、第7天，观察组引流液中炎性反应指标含量显著低于对照组，二者之间的差异存在统计学意义（P<0.05）。结论：三黄煎剂有效改善术后中医临床症状与炎性反应表现，显著降低乳腺癌手术创面炎性反应水平，有利于术后恢复并潜在改善乳腺癌预后。 |
| English Summary: |
| To observe the clinical efficacy of San Huang decoction(SHD) on improving inflammation of surgical wound after operation in patients with breast cancer and discuss its role in accelerating recovery and prognosis. Methods:A total of 30 breast cancer patients who met the inclusion/exclusion criteria were randomized in to treatment group(n＝15) and control group(n＝15). Patients in the control group were given routine treatment. On that basis, patients in the treatment group were given liquid SHD, one dose, twice a day. Treatment was given from 1 day before to surgery and 7 days after. Records measured include traditional Chinese medical symptoms, local wound inflammatory symptoms, quantity and sum of drainage fluid and the levels of C reactive protein (CRP)，Interleukin-6(IL-6) Interleukin-2 (IL-2), Interleukin-8(IL-8), tumor necrosis factor-alpha (TNF-α) from drainage fluid on the surgery day, and after 1, 3, and 7 days of surgery. Results:Compared to control group, traditional Chinese medical symptom scores decreased significantly in the treatment group (P<0.05) as well as the scores of surgical wound inflammatory symptoms. Drainage fluid was reduced significantly with 572.2 mL in the treatment group compared to 700.4 mL in the control group(P<0.05). Levels of CRP，IL-6, IL-2R,IL-8 and TNF-alpha were significantly lower in the treatment group at day 3 and 7 after surgery compared to those in the control group(P<0.05). Conclusion:SHD can effectively reduce the local wound inflammation and improve recovery after breast cancer operation. |
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