| 引用本文:陈睿1，赵萌2，朱利利1.中药泄浊除痹汤治疗痛风性关节炎疗效及安全性分析和抗炎作用机制[J].世界中医药,2017,(09):. |
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| 中药泄浊除痹汤治疗痛风性关节炎疗效及安全性分析和抗炎作用机制 |
| Discussion the Curative Effect and Mechanism of Zhongyaoxiezhuochubitang on Gouty Arthritis |
| 投稿时间：2016-09-09 |
| DOI：10.3969/j.issn.1673-7202.2017.09.029 |
| 中文关键词: 中药泄浊除痹汤 痛风性关节炎 膝关节 疗效 |
| English Keywords:Zhongyaoxiezhuochubitang Gouty arthritis Knee Curative effect |
| 基金项目:陕西省教育厅科学技术研究项目(2011658) |
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| 中文摘要: |
| 目的:观察中药泄浊除痹汤在治疗骨性关节炎方面的临床疗效,并借此探讨该方在SDF-1/CXCR4信号转导通路对骨关节炎的作用机制。方法:选取2013年7月至2015年12月宝鸡市中医医院收治的膝骨关节炎(KOA)患者52例,随机分成对照组和观察组,每组26例。对照组服用布洛芬缓释片,2片/d,1次/片,治疗10 d,观察组采用内服和外敷中药泄浊除痹汤,治疗10 d后观察2组治疗的临床疗效、各临床功能评分、药物不良反应、血浆IL-6及MMP-9水平的变化等情况。结果:1)治疗后观察组有效率88.46%,对照组有效率69.23%,2组有效率比较差异有统计学意义(P<0.05);2)2组患者治疗前症各评分及屈曲度比较,差异无统计学意义(P>0.05),治疗10 d后,HHS、Feller、屈曲度均升高,但对照组升高更明显,WOMAC、VAS均降低,对照组降低更明显,差异有统计学意义(P<0.05);3)不良反应中,对照组出现4例(15.38%),观察组1例(3.84%),观察组不良反应明显低于对照组(P<0.05);4)2组患者治疗前血浆IL-6及MMP-9水平比较差异无统计学意义(P>0.05)。治疗10 d后,2组的IL-6及MMP-9水平均较治疗前下降,但观察组下降更明显(P<0.05)。结论:中药泄浊除痹汤在治疗痛风性关节炎方面有显著的临床效果,且不良反应明显降低,值得推广,同时,该方可能通过目前热门的SDF-1/CXCR4信号转导通路,通过降低炎性反应水平,对痛风性关节炎起作用。 |
| English Summary: |
| To observe the effect of the Zhongyaoxiezhuochubitang in the treatment of gouty arthritis,and to discuss the party SDF-1 / CXCR4 signal transduction mechanisms of osteoarthritis.Methods:A total of 52 gouty arthritis patients who were admitted to our department in July 2013-December 2015,was randomly divided into control group and observation group 26 cases each.Control group was given diclofenac sodium sustained-release tablets,2/day,1/piece,for 10 days,the observation group oral and topical Zhongyaoxiezhuochubitang,the clinical efficacy of the treatment were observed 10 days after treatment,all clinical score,adverse drug reactions,IL-6 and other changes in plasma levels of MMP-9 and the case.Results:1)After observation group effective rate was 86.67%,the control effectiveness 68.89%,2 set of efficient comparative differences statistically significant(P<0.05);2)Two groups of patients before treatment was no disease each score and flexion significantly different(P>0.05),10 days after treatment,HHS,Feller,flexion were increased,but the control group increased more significantly,WOMAC,VAS decreased in control group reduced more significantly,the difference was statistically significant(P<0.05);3)adverse reactions,the control group had 4 cases(15.38%)in the observation group 1 cases(3.84%)observed adverse reactions was significantly lower than the control group group(P<0.05);4)two groups of patients before treatment plasma IL-6 and MMP-9 level difference was not statistically significant(P>0.05).10 days after treatment,IL-6 and MMP-9 levels decreased in both groups than before,but the observation group decreased more significantly(P<0.05).Conclusion:Zhongyaoxiezhuochubitang can achieve significant clinical efficacy,with the dignificant adverse reacions have not occurred,it is worthy to be promoted in the hospotal.Meanwhile,the drug may work on gouty arthritis through the current popular SDF-1 / CXCR4 signaling pathway reducing inflammation levels. |
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