To study the effectiveness and advantages of the intervention of Chinese herbal medicine in treating postmenopausal osteoporosis in winter based on the theory of kidney corresponding with the winter and kidney governing bone.Methods:A total of 64 patients with postmenopausal osteoporosis who were admitted and treated in Beijing Chaoyang TCM Hospital from July 2015 to November 2015, were divided into Chinese herbal medicine group (32 cases) and control group (32 cases).The treatment course for two groups were 75 days from Beginning of Winter (19th solar term) to Great Cold (24th solar term).Chinese herbal medicine group were treated with modified Erxian Decoction combined with conventional treatment, while the control group were receiving conventional treatment.The changes of bone degradation indexes including Type I collagen cross-linked N telopeptides, type I collagen cross-linked C-terminal telopeptide and calcitonin were observed before and after treatment, as well as in one year.Results:In the annual follow-up visit after treatment, the rising rates of CTX and NTX in Chinese herbal medicine were lowere than that in control group, but the difference was not statistically significant (P>0.05).The rising rate of CT in Chinese herbal medicine group was higher than that in control group, and the differences of CT level in two groups were statistically significant (P<0.05).Conclusion:Administration of Chinese herbal medicine with kidney nourishment in winter has certain effects on relieving bone degradation.Compared with control group, results show certain guiding significance in clinical practice.