| 引用本文:罗萌1，3，杨梅2，曾勇3.“智七针”对非痴呆型血管性认知功能障碍的影响及其部分机制研究[J].世界中医药,2017,(09):. |
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| “智七针”对非痴呆型血管性认知功能障碍的影响及其部分机制研究 |
| Study on Effects of “Intelligence Seven Needles” on Vascular Cognitive Impairment of Non-Dementiaand the Partial Mechanism |
| 投稿时间：2016-11-14 |
| DOI：10.3969/j.issn.1673-7202.2017.09.046 |
| 中文关键词: 血管性认知功能障碍 非痴呆型 智七针 JNK 磷酸化 |
| English Keywords:Vascular cognitive impairment Non-dementia Intelligence Seven Needles JNK Phosphorylation |
| 基金项目:国家自然科学基金项目(81173169) |
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| 中文摘要: |
| 目的:观察“智七针”对非痴呆型血管性认知功能障碍的临床疗效及探讨其部分机制。方法：选取2013年1月至2015年1月绵阳市中医院神经内科就诊的VCIND患者60例,随机分为对照组和观察组,每组30例,2组患者均口服多奈哌齐(5 mg/次,1次/d)或石杉碱甲(100 μg/次,2次/d),观察组在此基础上加“智七针”,1次/d,30 min/次,针刺5次/周。2组患者均连续治疗3个月,分别比较2组患者治疗前、治疗1个月及治疗3个月后蒙特利尔量表(Montreal scale,MoCA)、数字广度(Digit Span,DST)、听觉词语学习测试(Auditory Words Learning Test,AVLT)及语言流畅性测试(language fluency test,VFT)的变化,同时检测2组治疗前后外周血清JNK信号通路上标志性蛋白表达变化。结果:1)治疗1个月后观察组在MoCA总分、AVLT总分及VFT较治疗前明显增加,与对照组比较差异有统计学意义(P<0.05),而DST评分2组治疗后均较治疗前改善(P<0.05),但治疗后2组评分相仿(P>0.05)。治疗3个月后观察组MoCA、AVLT及VFT均明显优于对照组,差异均有统计学意义(P均<0.05)。DST评分2组治疗后3个月后组间差异无统计学意义(P>0.05)。2)2组治疗后pJNK浓度较治疗前下降,其中观察组下降趋势较明显(P<0.05)。结论:智七针可明显改善非痴呆型血管性认知功能障碍患者认知能力,其作用机制可能与降低JNK磷酸化有关。 |
| English Summary: |
| To observe the clinical curative effects of “Intelligence Seven Needles” on vascular cognitive impairment of non-dementia (VCIND),and to explore the partial mechanism.Methods:A total of 60 cases of patients with VCIND were included and randomly divided into the control group and the treatment group, 30 cases in each group.Both of the two groups were receiving oral administration of donepezil (5 mg/time, qd) or huperzine A (100 μg/time, bid), and the treatment group was added “Intelligence Seven Needles”, once a day, 30 min per time, and5 times per week.After continuous treatment for 3 months, the changes of Montreal scale (MoCA), digit span (DST), auditory verbal learning test (AVLT) and voice fluency test (VFT) between the two groups at the time that before treatment, 1 month and 3 months after treatment were compared, and trademark protein expression changes of JNK signaling pathway in the peripheral blood before and after the treatment between the two groups were detected.Results:1) MoCA score, AVLT score and VFT score were significantly increased after 1 month's treatment, and the differences were statistically significant compared with control group (P<0.05).The DST scores were improved in two groups after treatment (P<0.05), but the scores were similar in the two groups after treatment (P>0.05).MoCA, AVLT and VFT in the treatment group after three months' treatment were better than that in the control group, and the differences were statistically significant (P<0.05).There were no statistical differences of DST scores between the two groups after 3 months' treatment (P>0.05).2) The concentration of pJNK in the two groups decreased after treatment, and the decrease trend of the treatment group was more significantly (P<0.05).Conclusion:“Intelligence Seven Needles” can significantly improve the cognitive ability of patients with VCIND, and its mechanism may be associated with the lower of JNK phosphorylation. |
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