To investigate the application and safety of Zhitong Powder and TDP irradiation in adjuvant therapy of lumbar intervertebral disc pain.Methods:A total of 98 patients with lumbar intervertebral disc pain in our hospital from June 2015 to December 2016 were randomly divided into control group (n=49) and observation group (n=49).The 2 groups were given routine functional exercise and other treatment.The observation group was given Zhitong Powder and TDP irradiation，and the control group was given placebo and TDP irradiation.2 weeks was a course of treatment，and the 2 groups were continuously treated for 2 courses.Clinical therapeutic effects and adverse reactions of the 2 groups were evaluated after treatment，and the lumbar vertebral functional recovery and pain improvement of the 2 groups before and after treatment were assessed.The levels of serum inflammatory factors and platelet parameters were detected and compared.Results:After treatment，the total effective rate of the observation group was 81.63%，which was significantly higher than 61.22% of the control group (P<0.05).After treatment，the lumbar function scores of the 2 groups were higher than before treatment，and the observation group was higher than that of the control group.The ODI of the 2 groups were significantly lower than that before treatment，and the observation group was lower than the control group (P<0.01).Compared with that before treatment，the VAS score of the control group decreased and then increased from 1 week to 3 months after treatment，and the VAS score of the observation group decreased gradually (P<0.01).From 2 weeks to 3 months after treatment，the VAS score of the observation group was significantly lower than the control group (P<0.01).After treatment，the levels of serum MMP-3，IL-1β，GMP-140 in the 2 groups and PLT in the observation group were significantly lower than that before treatment，and the observation group was significantly lower than those in the control group (P<0.05 or P<0.01).Conclusion:The Zhitong Powder and TDP irradiation can improve the lumbar function and relieve the pain in the adjuvant therapy of patients with lumbar intervertebral disc pain.Its mechanism may be related to reducing the levels of inflammatory factors and improving ischemia-reperfusion，and the application has high safety，which is worthy of clinical application.