To investigate the clinical efficacy of Jianpi Shengxue granule in the treatment of iron deficiency anemia in children.Methods:A total of 219 cases who were treaded in outpatient department in our hospital from May 2015 to January 2017 and diagnosed as iron deficiency anemia according to the diagnosis criteria for the diagnosis of iron deficiency anemia were randomly divided into the treatment group (111 cases) and control group (108 cases).The treatment group was treated with Jianpi Shengxue granule，and the control group was treated with multidimensional iron oral liquid.One course of treatment last 1 month.The curative effects of two groups were observed.Results:The curative effect of treatment group was higher than that of the control group (χ2=5.76 P<0.05)，and the gastrointestinal adverse reactions were fewer (χ2=3.94 P<0.05).The recurrence rate after 6 months was low (χ2=3.94，P<0.05).Conclusion:The curative effect of Jianpi Shengxue granule in the treatment of children with iron deficiency anemia was significant，with few gastrointestinal adverse reactions and less recurrence，which is worthy of clinical promotion.