| 引用本文:张延君.益气活血膏方对气虚血瘀型脓毒症患者的临床疗效及对凝血指标的影响[J].世界中医药,2017,(10):. |
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| 益气活血膏方对气虚血瘀型脓毒症患者的临床疗效及对凝血指标的影响 |
| Clinical Efficacy of Yiqi Huoxue Plaster in the Treatment of Sepsis Patients with Qi Deficiency and Blood Stasis Pattern and Effects on Coagulation Indicator |
| 投稿时间：2017-03-27 |
| DOI：10.3969/j.issn.1673-7202.2017.10.013 |
| 中文关键词: 脓毒症 气虚血瘀症 益气活血膏方 凝血 抗凝 |
| English Keywords:Sepsis Qi deficiency and blood stasis pattern Yiqi Huoxue Plaster Blood coagulation Anticoagulation |
| 基金项目: |
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| 中文摘要: |
| 目的:探讨益气活血膏方对气虚血瘀型脓毒症患者的临床疗效及治疗前后患者凝血指标的变化。方法:选取2014年5月至2016年3月郑州市中医院收治的气虚血瘀型脓毒症患者79例，随机分为观察组（n=40）与对照组（n=39），对照组给予常规治疗，观察组在对照组的基础上联合益气活血膏方治疗，2组均连续治疗4周。统计2组临床疗效及临床症状改善情况；检测治疗前后2组血清凝血及抗凝指标水平；评价并比较治疗前后2组健康状况。结果:观察组临床总有效率为87.50%，明显高于对照组的66.67%（P<0.05）。与治疗前比较，治疗后对照组仅气短、乏力、舌象等症状积分明显降低（P<0.05），而观察组气短、乏力、神疲、自汗及舌象等症状积分均明显降低，且显著低于对照组（P<0.05）。与治疗前比较，治疗后2组部分凝血酶原时间（APTT）、凝血酶原时间（PT）均明显缩短（P<0.05），且2组间差异无统计学意义（P>0.05）；2组D-二聚体（D-D）水平明显降低，且观察组显著低于对照组（P<0.05）；观察组血小板（PLT）明显升高，且显著高于对照组（P<0.05）；与治疗前比较，治疗后2组血清抗凝血酶Ⅲ（AT-Ⅲ）及活化蛋白C（APC）水平均明显升高，APACHE-Ⅱ评分、SOFA评分均明显降低，2组差异有统计学意义（P<0.05）。结论:益气活血膏方可显著改善气虚血瘀型脓毒症患者的临床症状，有效调节其凝血因子及抗凝因子水平，促进凝血及抗凝平衡，降低血液黏度，可防止机体出血及血栓形成，疗效显著优于常规西药单用。 |
| English Summary: |
| To explore the clinical efficacy of Yiqi Huoxue Plaster in the treatment of sepsis patients with qi deficiency and blood stasis pattern and its effects on coagulation indicator. Methods:A total of 79 sepsis patients with qi deficiency and blood stasis pattern who were admitted and treated in Zhengzhou TCM Hospital from May 2014 to March 2016 were selected. All patients were randomly divided into control group (n=39) and observation group (n=40). The control group was treated with conventional western medicine treatment, while the observation group wase treated combined with Yiqi Huoxue Plaster on the basis of conventional treatment. Two groups were treated for 4 weeks continuously. The clinical efficacy and the improvement of clinical symptoms were recorded, and the serum coagulation and anti-coagulation indicators before and after treatment were detected. The physical condition of 2 groups before and after treatment were evaluated and compared. Results:The total effective rate of the patients in the observation group (87.50%) was significantly higher than that of the control group (66.67%) (P<0.05). Compared with the state before treatment, the symptoms integral of shortness of breath, lack of strength, tongue picture in control group decreased significantly after treatment (P<0.01), while the symptoms integral of shortness of breath, lack of strength, mental fatigue, spontaneous sweating and tongue picture in observation group decreased significantly, which was significantly lower than that in control group after treatment (P<0.01). Compared with the state before treatment, the APTT and PT of 2 groups shortened significantly after treatment (P<0.01), and there was no significant difference (P>0.05). The D-D levels of 2 groups decreased significantly, and that of observation group was lower than that of control group (P<0.01). The PLT of observation group increased significantly and higher than that of control group (P<0.05). Compared with the state before treatment, the levels of AT-Ⅲ and APC of 2 groups increased significantly, while the scores of APACHE and SOFA decreased significantly when compared with before treatment, with significant difference (P<0.01). Conclusion:Yiqi Huoxue Plaster can significantly improve the clinical symptoms of qi deficiency and blood stasis pattern of sepsis patients, regulate effectively the coagulation and anti-coagulation indicators, promote the blood coagulation and anticoagulation equilibrium, reduce the blood viscosity, and prevent hemorrhage and thrombosis. The clinical efficacy is superior to conventional western medicine alone. |
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