| 引用本文:董贵勇，李奉国，谭昶，吴燕梅，周亚琼.丹参辅助治疗对新生儿肺炎患儿的肺功能、凝血功能与血小板参数的影响[J].世界中医药,2017,(10):. |
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| 丹参辅助治疗对新生儿肺炎患儿的肺功能、凝血功能与血小板参数的影响 |
| Effects of Radix et Rhizoma Salviae Miltiorrhiza Adjuvant Therapy on Neonatal Pneumonia Patients' Lung Function，Blood Coagulation and Platelet Parameters |
| 投稿时间：2016-07-13 |
| DOI：10.3969/j.issn.1673-7202.2017.10.016 |
| 中文关键词: 丹参辅助治疗 新生儿肺炎 肺功能 凝血功能 血小板参数 |
| English Keywords:Salvia adjuvant therapy Neonatal pneumonia Lung function Blood coagulation function Platelet parameters |
| 基金项目:四川省卫生厅资助项目（20130598635） |
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| 中文摘要: |
| 目的：探究丹参辅助治疗对新生儿肺炎患儿的肺功能、凝血功能与血小板参数的影响。方法：选取2012年9月至2014年10月广元市中医院收治的新生儿肺炎患儿160例，按照简单数字表法随机分为观察组和对照组。每组80例。对照组接受抗感染等常规治疗，观察组在对照组基础上增加丹参注射液辅助治疗，分别于治疗前后测定2组肺炎患儿肺功能、凝血功能与血小板各参数水平。结果：对于肺功能，治疗后，对照组患儿有6项指标与治疗前比较，差异有统计学意义（P<0.05），3项指标虽有改观，但差异无统计学意义（P>0.05）；而观察组所有肺功能测试指标均得到显著改善，差异有统计学意义（P<0.05）且其改善效果优于对照组。对于凝血功能，对照组活化部分凝血活酶时间（Activated Partial Thromboplastin Time，APTT）、凝血酶原时间（Prothrombin Time，PT）、凝血酶时间（Thrombin Time，TT）与治疗前比较显著下降，差异有统计学意义（P<0.05），纤维蛋白原（Fibrinogen，FIB）水平有所提高但与治疗前比较，差异无统计学意义（P>0.05）；观察组4项指标与治疗前比较，差异有统计学意义（P<0.05），治疗后观察组PT、TT及APTT指标显著低于对照组，差异有统计学意义（P<0.05），FIB值改善效果优于对照组。对于血小板参数，治疗后2组患者各血小板指标均得到了显著改善，差异有统计学意义（P<0.05）且观察组改善程度比较对照组更明显，差异有统计学意义（P<0.05）。结论：丹参辅助治疗比较常规疗法能显著改善新生儿肺炎患儿的肺功能、凝血功能、血小板参数，且该疗法实惠经济，值得临床推广。 |
| English Summary: |
| To investigate the effects of Radix et Rhizoma Salviae Miltiorrhiza adjuvant therapy on neonatal pneumonia patients' lung function，blood coagulation and platelet parameters.Methods:A total of 160 patients with neonatal pneumonia who were admitted and treatment in our hospital from September 2012 to October 2015 were selected.By using lot method，all patients were randomly divided into control group and Radix et Rhizoma Salviae Miltiorrhiza group (salvia group)，with 80 patients in each group.The patients of control group were received conventional anti-infection treatment and the patients of salvia group were added salvia adjuvant therapy based on conventional treatment.The lung function，blood coagulation and platelet parameters of all patients before and after treatment were detected.Results:As for lung function，6 indicators were significant improved (P<0.05) and 3 indicators had improved but not significantly (P>0.05) in control group.Otherwise，all indicators showed significant improvment (P<0.05) compared with pre-treatment in salvia group，which had better effect than control group.As for blood coagulation function，the activated partial thromboplastin time (APTT)，prothrombin time (PT) and thrombin time (TT) decreased significantly compared with pretreatment (P<0.05)，and the concentration of fibrinogen (FIB) increased but the difference was not significant (P>0.05) in control group.However，the difference of APTT，PT，TT and FIB pre/pro-treatment in salvia group were all statistically significant (P<0.05)，especially the level of APTT，PT and TT in salvia group were significantly decreased (P<0.05) compared with control group，and FIB also improved more significantly.As for platelet parameters，both groups were improved significantly (P<0.05) compared with pretreatment and salvia group showed better improving effect than control group.Conclusion:Salvia adjuvant therapy can significantly improve the neonatal pneumonia patients' lung function，blood coagulation and platelet parameters compared with conventional treatment，which is both economic and effective and worthy of clinical promotion. |
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