| 引用本文:楚选云.鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的疗效及对鼻纤毛传输功能的影响[J].世界中医药,2017,(10):. |
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| 鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的疗效及对鼻纤毛传输功能的影响 |
| Therapeutic Effects of Biyuan Tongqiao Granule Combined with Triamcinolone Acetonide Nasal Spray in the Treatment of Chronic Rhinosinusitis and its Effects on Nasal Mucociliary Transport Function |
| 投稿时间：2017-08-21 |
| DOI：10.3969/j.issn.1673-7202.2017.10.028 |
| 中文关键词: 慢性鼻-鼻窦炎 鼻渊通窍颗粒 曲安奈德鼻喷雾剂 疗效 鼻纤毛传输功能 |
| English Keywords:Chronic rhinosinusitis Biyuan Tongqiao granule Triamcinolone acetonide nasal spray Efficacy Nasal mucociliary transport function |
| 基金项目:河南省医学科技攻关计划项目（201204149） |
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| 中文摘要: |
| 目的:探讨鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎(CRS)的疗效及对鼻纤毛传输功能的影响。方法:选取2015年4月至2017年1月南阳市第一人民医院收治的CRS患者126例,随机分为观察组和对照组，每组63例,2均采用曲安奈德鼻喷雾剂治疗,观察组在此基础上联合鼻渊通窍颗粒治疗,2组均连续治疗10周。比较2组临床治疗效果;评价并比较2组临床症候评分变化;检测并比较2组鼻纤毛传输功能和炎性因子水平变化。结果：观察组总有效率为87.30%,较对照组的71.43%显著升高(P<0.05);与治疗前比较,治疗后2组头晕头痛、流涕、鼻塞、嗅觉下降和喷嚏等临床症候评分均显著降低,且观察组低于对照组(P<0.05或P<0.01);与治疗前比较,治疗后2组MTT均显著降低,且观察组低于对照组(P<0.01);与治疗前比较,治疗后2组IL-2、IL-5、IL-6、IL-8水平均显著下降,且观察组低于对照组(P<0.05或P<0.01)。结论：鼻渊通窍颗粒联合曲安奈德鼻喷雾剂能提高CRS患者鼻纤毛传输功能,降低患者炎性反应,缓解患者临床症状,临床效果显著。 |
| English Summary: |
| To explore the efficacy of Biyuan Tongqiao granule combined with triamcinolone acetonide nasal spray in the treatment of chronic rhinosinusitis (CRS) and its effects on nasal mucociliary transport function.Methods:A total of 126 cases of CRS patients who were treated in our hospital from April 2015 to January 2017 were selected and randomly divided into treatment group (n=63) and control group (n=63).The 2 groups were treated with triamcinolone acetonide nasal spray，and the treatment group was treated with Biyuan Tongqiao granules on this basis.The 2 groups were treated continuously for 10 weeks.The clinical efficacy of the 2 groups was compared.The changes of clinical symptom scores in the 2 groups were evaluated and compared.The changes of nasal mucociliary transmission and inflammatory factors between the 2 groups were detected and compared.Results:The total efficiency of the treatment group was 87.30%，which was significantly higher than 71.43% of the control group (P<0.05); compared with that before treatment，the scores of clinical symptom such as dizziness headache，nasal discharge，nasal congestion，olfaction decline and sneezing of the 2 groups after treatment significantly reduced，and the treatment group was lower than the control group (P<0.05 or P<0.01); compared with that before treatment.MTT of the 2 groups after treatment significantly decreased，and the treatment group was lower than the control group (P<0.01); compared with that before treatment，the levels of IL-2，IL-5，IL-6，IL-8 of the 2 groups after treatment significantly decreased，and the treatment group was lower than the control group (P<0.05 or P<0.01).Conclusion:Biyuan Tongqiao granule combined with triamcinolone acetonide nasal spray can improve the nasal mucociliary transport function of CRS patients，reduce the inflammation，relieve the clinical symptoms with remarkable efficacy. |
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