| 引用本文:徐如冰，马政瑶，贾永艳.星点设计优选归红活血凝胶膏剂基质处方[J].世界中医药,2017,(10):. |
|
| 星点设计优选归红活血凝胶膏剂基质处方 |
| Central Composite Design in Optimized Selection of Matrix Formulation of Guihong Huoxue Gel Paste |
| 投稿时间：2016-10-27 |
| DOI：10.3969/j.issn.1673-7202.2017.10.047 |
| 中文关键词: 凝胶贴膏剂 基质处方 单因素试验 星点设计 |
| English Keywords:Gel paste Matrix formulation Single-factor Central composite design |
| 基金项目:河南省协同创新中心创新基金项目(201521)——呼吸疾病诊疗与新药研发 |
|
| 摘要点击次数: 1010 |
| 全文下载次数: 796 |
| 中文摘要: |
| 目的：优化归红活血凝胶膏剂的基质处方。方法：采用单因素考察法考察各个因素对基质性能的影响。选择影响最大的3个因素作为星点设计的考察因素，以综合评分为考察指标，进行实验预测最优处方，并进行验证。结果：归红活血镇痛凝胶膏剂基质的最佳配比为：NP-700 2.38 g，PVP-K90 2.25 g，甘羟铝1.0 g，酒石酸0.15 g，EDTA 0.025 g，高岭土2 g，甘油19 g，1.2-丙二醇8 g，CMC-Na红花水提溶液43 g，中药浸提物10 g。结论：按最佳基质处方配比制备的凝胶膏剂外观平整光滑，黏度适中，皮肤追随性好，性能良好。 |
| English Summary: |
| To optimize the matrix formulation of the Guihong Huoxue gel paste.Methods:The effects of various factors on the properties of matrix were investigated by single factor investigation.The three factors with largest effects were selected as the study factors of central composite design.The optimal prescription was predicted by the comprehensive score，and would be verified by clinical practice.Results:Guihong Huoxue analgesic gel paste matrix optimum of ratio was：NP-700 2.38 g，PVP-K90 2.25 g，aluminium glycinate 1 g，tartaric acid 0.15 g，EDTA 0.025 g，kaolin 2 g，glycerin 19 g，propylene glycol 8 g，CMC-Na-water extract of safflower 43 g，ointment 10 g.Conclusion:The Guihong Huoxue of the optimal preparation matrix formula of analgesic gel paste looks smooth，moderate viscosity，good skin following and good performances. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
