Study on Characteristics of Accompanying Patterns with Qi Deficiency Pattern and Its Influencing Factors in Patients with Colorectal Cancer after Operation
To investigate the characteristics and influence factors of the pattern elements accompanied with qi deficiency in the postoperative colorectal patients.Methods:A total of 78 postoperative colorectal patients with qi deficiency who were identified by using the method of differentiation of pattern elements.The characteristics of complicated pattern elements were studied and the effects of gender,chemotherapy,tumor site,TNM staging and GSTP1 genetic polymorphism were analyzed by comparing the frequency of pattern elements in different groups.Results:All the qi deficiency patients were accompanied with at least 1 other pattern element.Among 14 common pattern elements with frequency higher than 10%,yang deficiency,qi stagnation and blood deficiency ranked the first to third highest frequency pattern elements.The frequency of blood deficiency,spleen and kidney were higher in the female than in the male while the frequency of heat pattern was higher in the male than in the female.And the frequency of liver pattern increased significantly in the patients undergoing chemotherapy compared with that in the non-chemotherapy patients.The colon pattern frequency was significantly higher in the TNM IV stage patients than in the II and III stage patients.Furthermore the analysis on GSTP1 genetic polymorphisms showed the frequency of spleen reduced in turn in the patients carrying A/A,A/G and G/G genotypes.The difference was statistically significant (P<0.05).Conclusion:The postoperative colorectal cancer patients with qi deficiency were accompanied with other pattern commonly,and simultaneous occurrence of deficiency and excess patterns coexisted in body.Gender,chemotherapy,tumor staging and GSTP1 genetic polymorphisms can affect the frequency of pattern elements accompanying with qi deficiency.