Chinese materia medica has complex compositions. Most Chinese materia medica played the pharmacology role after being absorbed into the body through the gastrointestinal tract and acting with the targets. The variety, processing, dose, compatibility and other factors affect in vivo process of drug. The study on in vivo dynamic changes was important for the explanation of toxicity-efficacy of Chinese materia medica. The research group applied pharmacokinetics in the study of 'enhancing efficiency and reducing toxicity" of Chinese materia medica, and explored the ideas and methods of pharmacokinetics/pharmacodynamics integrated analysis.