| 引用本文:李芸霞，彭成.基于毒效整合分析的附子药动学、药效学研究[J].世界中医药,2017,(11):. |
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| 基于毒效整合分析的附子药动学、药效学研究 |
| Study on Pharmacokinetics/pharmacodynamics of Radix Aconiti Lateralis Praeparata based on Toxicity-efficacy Integrated Analysis |
| 投稿时间：2017-10-09 |
| DOI：10.3969/j.issn.1673-7202.2017.11.006 |
| 中文关键词: 附子 药动学 药效学 毒效整合分析 |
| English Keywords:Radix Aconiti Lateralis Praeparata Pharmacokinetics Pharmacodynamics Toxicity-efficacy integrated analysis |
| 基金项目:国家自然科学基金重点项目(81630101);国家发改委标准化项目(ZYBZH-C-SC-51);国家自然科学基金面上项目(81573583);四川省中医药管理局“川产道地药材综合开发与区域发展”项目(2016ZY008);四川省科技厅青年科技创新研究团队专项(2017TD0001) |
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| 中文摘要: |
| 中药成分复杂,大多数中药药效的发挥需要在经胃肠道吸收进入到体内与靶点相互作用后发生。而中药的品种、炮制、剂量、配伍等因素均会影响到药物的体内过程。研究中药在体内动态变化过程对于其毒效研究至关重要。课题组将药动学应用于中药减毒增效研究中,并探索了中药药动学/药效学整合分析的思路与方法。 |
| English Summary: |
| Chinese materia medica has complex compositions. Most Chinese materia medica played the pharmacology role after being absorbed into the body through the gastrointestinal tract and acting with the targets. The variety, processing, dose, compatibility and other factors affect in vivo process of drug. The study on in vivo dynamic changes was important for the explanation of toxicity-efficacy of Chinese materia medica. The research group applied pharmacokinetics in the study of 'enhancing efficiency and reducing toxicity" of Chinese materia medica, and explored the ideas and methods of pharmacokinetics/pharmacodynamics integrated analysis. |
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