| 引用本文:韩波，黄维，谢欣，彭成.有毒乌头类中药的毒效网络整合分析:思路与方法[J].世界中医药,2017,(11):. |
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| 有毒乌头类中药的毒效网络整合分析:思路与方法 |
| Thought and Methodology of Toxicity-efficacy Network Integrated Analysis of Toxic Aconitum |
| 投稿时间：2017-10-09 |
| DOI：10.3969/j.issn.1673-7202.2017.11.007 |
| 中文关键词: 有毒中药 乌头类中药 毒效网络 系统毒理学 网络药理学 |
| English Keywords:Toxic Chinese materia medica Aconitum Toxicity-efficacy networks Systems toxicology Network pharmacology |
| 基金项目:国家自然科学基金重点项目(81630101);国家发改委标准化项目(ZYBZH-C-SC-51);国家自然科学基金国家基础科学人才培养基金(J1310034);四川省中医药管理局“川产道地药材综合开发与区域发展”项目(2016ZY008) |
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| 中文摘要: |
| 中药的有效性和安全性不仅是中医药传承和发展的坚实基础,也是中医药服务于世界人民健康事业的根本前提。因此多学科交叉融合、整合分析中药毒效的物质基础、作用原理、毒效关系,揭示“有故无殒、中病即止”的科学内涵,是中药进入国际医药市场亟待解决的关键问题。利用复杂生物网络研究中药系统药理学和系统毒理学,构建可靠的中药药效物质作用靶标相关的分子效应和毒理学性质网络,反映特定疾病状态的相关生物实体的分子网络及毒性机制,整合效应物质作用靶标网络与疾病生物网络,通过网络拓扑学和动力学等方法分析“药物-靶点-疾病”网络和“药物-靶点-活性/毒性”网络中有效物质与疾病、成分与毒性的相互作用关系,检识出复杂网络模型中的靶点组合、通路组合、子网组合、药物组合等,大大提高了中药复杂药效物质的研究效率。作者主要基于其研究团队近年来开展的乌头类中药研究工作,重点介绍开展有毒中药的毒效网络整合分析研究的思路和方法。 |
| English Summary: |
| Efficacy and safety are not only the solid foundation of traditional Chinese medicine (TCM)'s heritage and development, but also the fundamental premise of TCM serving the health of people in the world. Therefore, integrated analyzing the material basis, action mechanism and toxicity-efficacy relationship of Chinese materia medica's efficacy and safety through multidisciplinary, in addition to revealing the scientific connotation “There is no death, drugs should be removed after recover.”, are the key problems to be solved in the process Chinese materia medica becoming one of the most important industries in the international market. Studying systems pharmacology and systems toxicology by utilizing complex biological networks, constructing reliable molecular effect and toxicological property networks related to Chinese materia medica targets, reflecting molecular network and toxic mechanism of related biological entity under specific disease state, integrating effect material active target networks and disease biological networks, analyzing relationships between active substance and disease, components and toxicity in “drug-target-disease” networks and “drug-target-activity/toxicity” networks using network topology and dynamics methodology, identifying target combination, pathway combination, subnet combination, drug combination, have highly improved the researching efficiency of Chinese materia medica complex pharmacodynamic substances. Mainly based on studies of Aconitum by the author's group, this article illustrated approach to and methodology of toxicity-activity networks integrated analysis research on toxic Chinese materia medica. |
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