| 引用本文:王健，孙宏普，韩生先，杨庚.十全大补汤对结直肠癌术后化疗患者减毒增效及免疫功能的影响[J].世界中医药,2017,(11):. |
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| 十全大补汤对结直肠癌术后化疗患者减毒增效及免疫功能的影响 |
| Effect of Shiquan Dabu Decoction on Toxicity Reducing and Efficacy Enhancing and Immune Function in Colorectal Cancer Patients with Postoperative Chemotherapy |
| 投稿时间：2016-12-28 |
| DOI：10.3969/j.issn.1673-7202.2017.11.012 |
| 中文关键词: 十全大补汤 结直肠癌 化疗 减毒增效 免疫功能 |
| English Keywords:Shiquan Dabu decoction Colorectal cancer Chemotherapy Toxicity reducing and efficacy enhancing Immune function |
| 基金项目:河南省医学科技攻关计划项目(201204157) |
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| 中文摘要: |
| 目的：探讨十全大补汤对结直肠癌术后化疗患者减毒增效及免疫功能的影响。方法：选取2015年2月至2016年3月洛阳市第二中医院收治的结直肠癌患者98例，随机分为对照组（n＝49）与观察组（n＝49）。对照组患者采用FOLFOX4化疗方案进行化疗，观察组在对照组基础上应用十全大补汤治疗。比较2组治疗前后临床症状、外周血T淋巴细胞亚群（CD3+、CD4+、CD8+）的变化及不良反应，并评价2组临床疗效。结果：观察组治疗有效率为81.63%（40/49），高于对照组61.22%（30/49），差异有统计学意义（P<0.05）；治疗后观察组CD3+、CD4+均上升，中医症候积分均下降，且观察组上述观察指标均优于对照组，差异有统计学意义（P<0.05）；观察组白细胞减少、胃肠道不适、脱发、恶心呕吐发生率均低于对照组，差异有统计学意义（P<0.05）。结论：对结直肠癌术后化疗患者采用十全大补汤，可显著提高临床疗效，缓解临床症状，减少化疗所致的不良反应，增强患者免疫功能，促进身体恢复，具有临床推广意义。 |
| English Summary: |
| To observe the effect of Shiquan Dabu decoction on toxicity reducing and efficacy enhancing and immune function in colorectal cancer patients with postoperative chemotherapy.Methods:A total of 98 colorectal cancer patients admitted into our hospital from February 2015 to March 2016 were randomly divided into control group (n＝49) and observation group (n＝49).The control group took FOLFOX4 chemotherapy regimen,and the observation group took Shiquan Dabu decoction on the basis of the control group.The clinical symptoms,changes of peripheral blood T lymphocyte subsets (T cell subset,CD3+,CD4+,CD8+),toxic and side effects of two groups before and after treatment were compared,and the clinical efficacy of two groups were evaluated.Results:The total effectively rate of the observation group was 81.63%(40/49),which was higher than 61.22%(30/49) of the control group (P<0.05).Compared with pre-treatment,the CD3+,CD4+ of observation group increased and TCM symptom score decreased after treatment,and the above-mentioned indexes of observation group were better than control group (P<0.05); The incidence of leukopenia,intestinal discomfort,alopecia,nausea and vomiting in observation group was lower than control group (P<0.05).Conclusion:Shiquan Dabu decoction for colorectal cancer patients with postoperative chemotherapy can significantly increase clinical efficacy,relieve clinical symptom,reduce toxic and side effects caused by chemotherapy,strengthen immune function,and enhance body recovery,which has significance of clinical generalization. |
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