| 引用本文:邵志英1，朱敏蓉1，陆俊2，周煜宗3.中西医治疗联合丙种球蛋白对新生儿肺炎的疗效观察[J].世界中医药,2017,(11):. |
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| 中西医治疗联合丙种球蛋白对新生儿肺炎的疗效观察 |
| Observation on Curative Effects of Traditional Chinese and Western Medicine Combined with Gamma Globulin on Neonatal Pneumonia |
| 投稿时间：2017-10-21 |
| DOI：10.3969/j.issn.1673-7202.2017.11.016 |
| 中文关键词: 中西医治疗 丙种球蛋白 新生儿肺炎 疗效观察 |
| English Keywords:Integrated traditional Chinese and western medicine Gamma globulin Pneumonia of newborn Curative effect |
| 基金项目:国家中医药管理局国家中医重点专科（ZK0901EK010） |
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| 中文摘要: |
| 目的：观察中西医治疗联合丙种球蛋白对新生儿肺炎的临床疗效。方法：选取2015年6月至2017年7月在上海市浦东新区妇幼保健院住院治疗的新生儿肺炎患儿100例为研究对象，随机分为对照组和观察组，对照组给予中西医结合治疗，观察组在对照组的基础上给予丙种球蛋白辅助治疗。分别于治疗前和治疗后采集2组肺炎新生儿静脉的外周血，检测T淋巴细胞变化以及B细胞抗体水平（包括CD4+、CD8+T淋巴细胞比例；CD4+/CD8+比值以及血清IgG、IgA、IgM水平）；同时对2组肺炎新生儿的临床疗效进行评价。结果：与治疗前比较，观察组肺炎新生儿各项体征和临床症状较对照组改善显著,临床有效率和治愈率显著提高(P0.05)；对照组CD4+、CD8+T淋巴细胞比例；CD4+/CD8+比值以及血清IgG、IgA、IgM水平无显著变化（P>0.05）。观察组CD4+、CD8+T淋巴细胞比例；CD4+/CD8+比值以及血清IgG、IgA、IgM水平显著升高(P<0.05)。结论：中西医治疗联合静脉注射丙种球蛋白能够有效改善肺炎新生儿各项临床体征和症状，缩短病程，提高治疗有效率和治愈率。并显著增强肺炎新生儿机体的免疫功能，临床效果显著，是值得推广使用的新生儿肺炎辅助治疗方法。 |
| English Summary: |
| To observe the clinical efficacy of combination of traditional Chinese medicine and Western medicine and gamma globulin in the treatment of neonatal pneumonia. Methods:A total of 100 cases of neonatal pneumonia treated in our hospital from June 2015 to July 2017 were randomly divided into the control group and the observation group. The control group was given the combination treatment of traditional Chinese medicine and Western medicine. The observation group was treated with gamma globulin adjuvant therapy on the basis of the control group. The peripheral blood samples of 2 groups of neonates with pneumonia were collected before and after treatment respectively. The changes of T lymphocyte and the level of B cell antibody (including CD4+, CD8+T lymphocyte ratio, CD4+/CD8+ratio, and serum IgG, IgA, IgM levels) were detected. At the same time, the clinical efficacy of 2 groups of neonatal pneumonia was evaluated. Results:Compared with before treatment, the signs and clinical symptoms of the neonatal pneumonia in the observation group were significantly improved compared with the control group, and the clinical effective rate and cure rate were significantly improved (P<0.05). CD4+, CD8+T lymphocyte ratio, CD4+/CD8+ratio, serum IgG, IgA and IgM levels did not change significantly in the control group (P>0.05). CD4+, CD8+T lymphocyte ratio, CD4+/CD8+ratio, serum IgG, IgA and IgM levels were significantly increased in the observation group (P<0.05). Conclusion:Traditional Chinese medicine combined with intravenous injection of gamma globulin can effectively improve the clinical signs and symptoms of neonatal pneumonia, shorten the course of disease, improve the effective rate and cure rate of pneumonia. And also it can significantly enhance the immune function of the neonatal pneumonia, with significant clinical effects, which is worthy of promotion for the use of adjuvant treatment of neonatal pneumonia. |
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