| 引用本文:张力，李方玲，马丽.六味地黄丸联合西药治疗轻、中度阿尔茨海默病的临床观察[J].世界中医药,2017,(11):. |
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| 六味地黄丸联合西药治疗轻、中度阿尔茨海默病的临床观察 |
| Clinical Observation on Liuwei Dihuang Pill Combined with Western Medicine in the Treatment of Mild to Moderate Alzheimer's Disease |
| 投稿时间：2017-10-21 |
| DOI：10.3969/j.issn.1673-7202.2017.11.023 |
| 中文关键词: 阿尔茨海默病 肾阴亏虚 六味地黄丸 多奈哌齐 |
| English Keywords:Alzheimer's disease Kidney yin deficiency Liuwei Dihuang Pill Donepezil |
| 基金项目:北京市卫计委课题（H01-2014-123）——阿尔茨海默病病理生理分子机制系列研究 |
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| 中文摘要: |
| 目的：观察六味地黄丸联合常规西药治疗轻、中度阿尔茨海默病（AD）的临床效果，初步探讨六味地黄丸治疗AD的机制。方法：选取2015年3月至2016年8月北京老年医院接受治疗的髓海不足、肾阴亏虚型轻、中度AD患者76例作为研究对象，随机分为对照组和联合组，每组38例。其中对照组患者给予盐酸多奈哌齐片治疗，联合组患者在此次基础上给予六味地黄丸。比较2组患者的治疗效果及治疗前后中医症状积分、简易智能状态检查表（MMSE）评分、AD评估量表认知部分（ADAS-cog）评分、日常生活能力量表评分（ADL）变化情况。结果：联合组治疗总有效率明显高于对照组（P<0.05）；治疗后2组患者的MMSE、ADAS-cog及ADL评分均明显得到改善，且治疗后联合组上述指标均明显优于对照组（P<0.05）；治疗后对照组患者中医症状积分无明显变化（P>0.05），联合组则明显降低，且与对照组比较具有统计学意义（P<0.05）。结论：六味地黄丸联合常规西药治疗轻中度AD效果显著，可明显改善患者的智力情况和生活能力，同时还可显著改善患者的中医症候，值得临床推广应用。 |
| English Summary: |
| To observe the clinical effects of Liuwei Dihuang Pill combined with western medicine in the treatment of mild to moderate Alzheimer's disease (AD), and to explore the mechanism of the treatment of AD with the Liuwei Dihuang pill. Methods:A total of 76 cases of insufficient marrow and deficiency of kidney yin syndrome mild and moderate AD patients who were treated in our hospital from March 2015 to August 2016 were randomly divided into control group and combination group, with 38 cases in each group. The control group was treated with Donepezil Hydrochloride Tablets, and the combined group was given Liuwei Dihuang pill. The treatment effects and the TCM symptoms integral, Mini Mental State Examination (MMSE) score, AD cognitive assessment scale (ADAS-cog) score, ADL score (ADL) changes of 2 groups before and after treatment were compared. Results:The total effective rate of treatment group was significantly higher than the control group (P<0.05); MMSE, ADAS-cog and ADL scores of 2 groups were significantly improved after treatment, and the control group were significantly better than the group (P<0.05); TCM symptoms integral of control group had no significant change (P>0.05), and was significantly reduced in the combination group with significant difference when compared with control group (P<0.05). Conclusion:Liuwei Dihuang pills combined with conventional western medicine in the treatment of mild and moderate AD has significant efficacy, can significantly improve the intelligence and life ability of patients, but also can significantly improve the symptoms of patients, which is worthy of clinical application. |
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