世界中医药

目的:探讨热毒宁联合葡萄糖酸锌治疗小儿腹泻的疗效及对细胞免疫学的影响。方法:选取2015年4月至2016年9月盘锦市中心医院辽河院区收治的腹泻患儿102例，按照随机数表法分为观察组（n＝51）和对照组（n＝51），对照组采用蒙脱石散治疗，观察组采用热毒宁联合葡萄糖酸锌治疗，比较2组患儿临床疗效，观察比较2组临床表现，检测并比较2组免疫学指标水平。结果:对照组临床治疗总有效率为76.47%，显著低于观察组的90.20%（P<0.05）；对照组大便频率与观察组差异无统计学意义（P>0.05），大便性状复常时间长于观察组（P<0.05）；与同组治疗前比较，治疗后2组红细胞C3b花环率（RC3bRR）、红细胞免疫复合物花环率（RICR）、红细胞免疫黏附促进因子（RFER）均显著升高，红细胞免疫黏附抑制因子（RFIR）显著下降（P<0.05），2组间差异有统计学意义（P<0.05）；与同组治疗前比较，治疗后2组CD3+、CD4+比例及CD4+/CD8+均显著升高（P<0.05），且观察组高于对照组（P<0.05），2组间及治疗前后CD8+比例无显著变化（P>0.05）；与同组治疗前比较，治疗后2组血清免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、粪便分泌型IgA（sIgA）水平均显著升高（P<0.01），且观察组高于对照组（P<0.05）。结论:热毒宁联合葡萄糖酸锌能改善腹泻患儿的临床症状及免疫功能，疗效显著。

English Summary:

To explore the curative effect of reduning injection combined with zinc gluconate in the treatment of infantile diarrhea and its effect on cellular immunity. Methods:A total of 102 cases of patients with infantile diarrhea in our hospital were selected and randomly divided into the treatment group (n＝51) and the control group (n＝51). The control group was treated with montmorillonite powder, and treatment group was treated with reduning injection combined with zinc gluconate. Clinical curative effect, clinical performance, immune index of 2 groups were compared. Results:The total clinical effective rate of the control group was 76.47%, which was significantly lower than 90.20% of the treatment group (P<0.05); there was no significant difference in stool frequency between 2 groups (P>0.05). The stool recovery time of the control group was longer than the treatment group (P<0.05); Compared with that before treatment, red cell C3b receptor rosette (RC3bRR), the red blood cell immune complex rosette (RICR), rosette forming enhancement rate (RFER) of 2 groups after treatment were significantly increased, and rosette forming inhibitor rate (RFIR) was significantly decreased (P<0.05 or P<0.01) with significant difference between 2 groups (P<0.05 or P<0.01); Compared with that before treatment, the ratio of CD3+, CD4+ and CD4+/CD8+ of 2 groups after treatment were significantly increased (P<0.05 or P<0.01), and the treatment group was higher than the control group (P<0.05 or P<0.01). There was no significant difference of CD8+ between 2 groups before and after treatment (P>0.05); Compared with that before treatment, the levels of serum immunoglobulin A (IgA), immunoglobulin G (IgG), fecal secretory IgA (sIgA) of 2 groups after treatment were significantly increased (P<0.01), and the treatment group was higher than the control group (P<0.05 or P<0.01). Conclusion:Reduning injection combined with zinc gluconate in the treatment of infantile diarrhea can improve the clinical symptom and immune function, with remarkable curative effect, which is worthy of promotion.

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