Observing clinical efficacy and the changes in T cell subgroup and immunoglobulin with stable chronic obstructive pulmonary disease(COPD) after treating with cooked powder of Sansang Shenqi decoction combined with conventional therapy.Methods:A total of 108 stable COPD patients were randomly divided into three groups.Thirty-six patients in conventional therapy group was given symbicort turbuhaler as the basic treatment.Thirty-six patients in Sansang Shenqi decoction combined with conventional therapy group was treated with Sansangshenqi decoction on the basis of conventional therapy.The rest of the patients were treated with cooked powder of Sansangshenqi decoction combined with conventional therapy.To observe the clinical efficacy of three groups and the influence on pulmonary function and quality of life,and the differences in T cell subgroup and inflammatory factors of these groups,as well as the comparison of different treatment groups' differences in cost of treatment.Results:The clinic effective rates of conventional therapy group,Sansang Shenqi decoction combined with conventional therapy group and cooked powder of Sansangshenqi decoction combined with conventional therapy group were 77.8%,97.2% and 94.4% respectively,which had a statistical significance(P<0.05).TCM syndrome scoring,quality of living evaluation,pulmonary function index (FEV1、FVC、FEV1%、FEV1/FVC) and changes of T cell subgroup and inflammatory factors were improved in both Sansang Shenqi decoction combined with conventional therapy group and cooked powder of Sansang Shenqi decoction combined with conventional therapy group as compared with that of conventional therapy group(P<0.05).However,there were no statistical significance(P>0.05) when compared with these two groups,indicating that these two groups had equivalent efficacy in the TCM syndrome scoring,quality of living evaluation,pulmonary function index and changes of T cell subgroup and inflammatory factors.Total expenses yearly of routine treatment in cooked powder of Sansangshenqi decoction combined with conventional therapy group was 5065.63±932.44 RMB,significantly less than that of the other two groups,which were 6415.85±1360.36 and 5760.70±1228.28 RMB(P<0.05).Conclusion:Stable COPD patients treating with cooked powder of Sansangshenqi decoction combined with conventional therapy showed significantly improvement in clinical efficacy,pulmonary function and quality of life,which also improving T cell subgroup and decreasing inflammatory factors expression and restores corticosteroid responses in COPD.