| 引用本文:刘玉娥1，胡亚俊1，裴学军2.健脾生血片比较蛋白琥珀酸铁口服溶液治疗妊娠期贫血的临床疗效观察[J].世界中医药,2017,(11):. |
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| 健脾生血片比较蛋白琥珀酸铁口服溶液治疗妊娠期贫血的临床疗效观察 |
| Observation on Clinical Effects of Jianpi Shengxue Tablet Compared with Iron Proteinsuccinylate Oral Solution in the Treatment of Patients with Gestational Iron Deficiency Anemia |
| 投稿时间：2017-10-21 |
| DOI：10.3969/j.issn.1673-7202.2017.11.038 |
| 中文关键词: 健脾生血片 蛋白琥珀酸铁口服溶液 妊娠期缺铁性贫血 临床疗效 |
| English Keywords:Jianpi Shengxue tablet Proteinsuccinylate oral solution Gestational iron deficiency anemia Clinical efficacy |
| 基金项目:武汉市科技攻关计划项目（2013070204020053） |
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| 中文摘要: |
| 目的：探讨健脾生血片治疗妊娠期缺铁性贫血的治疗效果，评估其临床疗效及安全性。方法：选择2014年8月至2016年1月华中科技大学同济医学院附属荆州医院就诊的妊娠期缺铁性贫血患者180例，分为对照组和观察组，各90例，对照组给予蛋白琥珀酸铁口服溶液，1支/次，2次/d；对照组给予健脾生血片，3片/次，3次/d。2组患者均连续治疗3个月。评估临床疗效、治疗前后红细胞计数（RBC）、血红蛋白（Hb）、红细胞比容(HCT)、红细胞平均体积(MCV)、血清铁蛋白(SF)、转铁蛋白饱和度（TSAT）、血清铁(SI)，记录所有不良反应。结果：2组治疗3个月后血生化指标RBC、Hb、HCT、MCV和铁代谢指标SF、TSAT和SI比较均有统计学意义（P<0.05），且观察组起效更快，指标在治疗1、2及3个月后均优于对照组（P<0.05）；治疗3个月后观察组贫血伴随临床症状显著改善且总有效率更高（P<0.05）；2组不良反应发生率比较差异无统计学意义（P>0.05）。结论：健脾生血片治疗妊娠期缺铁性贫血的疗效显著，并可改善贫血临床症状且安全可靠，值得临床推广应用。 |
| English Summary: |
| To explore the curative effect of Jianpi Shengxue tablet in the treatment of gestational iron deficiency anemia, and to evaluate the clinical curative effect and safety. Methods:A total of 180 patients with gestational iron deficiency anemia who were treated in our hospital from August 2014 to January 2016, were randomly divided into control group and observation group with 90 cases in each group. The control group was given Proteinsuccinylate Oral Solution, one drink one time, 2 times/d; The observation group received Jianpi Shengxue tablet, three tablets one time, 3 times/d. The treatment last for continuous three months. The clinical curative effects of the two groups were evaluated. Red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), Mean Corpuscular Volume (MCV), serum ferritin (SF), transferrin saturation (TSAT) and serum iron (SI) before treatment and after treatment were assessed and the adverse reactions were recorded. Results:After 3 months' treatment, the biochemical indicators such as RBC, Hb, HCT， MCV and Iron metabolism indexes such as SF, TSAT and SI levels in 2 groups were higher than that of pre-therapy (P<0.05), while the observation group took effect faster (P<0.05). The indexes were better than the control group in 1, 2 and 3 months after treatment (P<0.05); After 3 months, the symptom of anemia in observation group was significantly improved and the total effective rate was higher (P<0.05); The adverse reactions of the observation group had no significant difference compared with the control group (P<0.05). Conclusion:There is a significant curative effect of Jianpi Shengxue tablet in the treatment of gestational iron deficiency anemia. It can improve anemia clinical symptoms with safety, which is worthy of clinical application. |
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