To observe the therapeutic effect of acupuncture combined with modified Zi Sheng Tang in treatment of chronic atrophic gastritis of spleen and stomach deficiency type.Methods:A total 78 cases of chronic atrophic gastritis of deficiency of spleen and stomach type were randomly divided into Zi Sheng Tang modified group and the acupuncture combined with Zi Sheng Tang group with 39 cases in each.Treatment course lasts for 49 days.Acs-Points chosen were Weishu (B-21),Pi Shu,and Zhong Wan(CV-12).Clinical symptoms,pathological and gastroscopy examination were analyzed to estimate the efficacy of the two groups before and after treatment.The cyclooxygenase-1(COX-1),glutathione stransferase-π (GST-π) and whole blood reductive viscosity (RV) were detected.Results:One case dropped in Zi Sheng Tang group and two cases dropped in Zi Sheng Tang combined with acupuncture group.Total effect rate of improving clinical symptoms,pathological and gastroscopy indicators of the combined group is higher than those of the Zi Sheng Tang group (all P<0.01).After treatment,the score of GST-π,COX-1 and RV have improved significantly (all P<0.05) in two groups.Conclusion:Acupuncture combined with Zi Sheng Tang is significantly effective in treating chronic atrophic gastritis of deficiency of spleen and stomach type.