| 引用本文:李思敏1，包洁2，汪琴静3，窦晓兵2，范永升2.氧化应激与实热“上火”的相关性研究[J].世界中医药,2017,(12):. |
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| 氧化应激与实热“上火”的相关性研究 |
| Study on Correlation between Oxidative Stress and Excess Heat “Shang huo” |
| 投稿时间：2017-11-03 |
| DOI：10.3969/j.issn.1673-7202.2017.12.002 |
| 中文关键词: 实热“上火” 氧化应激 MDA ROS GSH T-AOC SOD |
| English Keywords:Excess-heat “shanghuo” Oxidative stress MDA GSH T-AOC SOD ROS |
| 基金项目:国家重点基础研究发展计划（973计划）项目（2014CB543001） |
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| 中文摘要: |
| 目的：通过检测观察组血液中过氧化指标（MDA、ROS）和抗氧化指标（GSH、T-AOC、SOD）的变化，探讨氧化应激与实热“上火”的相关性。方法：分别收集临床实热“上火”和正常人群的样本，检测其血浆中MDA、GSH、SOD、T-AOC水平和外周血白细胞中ROS含量，进行比较。结果：与对照组比较，观察组血浆中MDA、GSH、SOD、T-AOC浓度水平均升高，差异有统计学意义（P<0.05)，而白细胞内的ROS含量显著下降，差异有统计学意义（P<0.01）。结论：观察组过氧化指标与抗氧化指标均有显著变化，说明实热“上火”与氧化应激密切相关，观察组机体处于过氧化与抗氧化相互交争状态，但氧化与抗氧化水平尚且处于平衡阶段。 |
| English Summary: |
| To study the correlation between oxidative stress and excess heat “shanghuo” through observing the changes of blood lipid peroxidation index (MDA, ROS) and antioxidant indexes (GSH, T-AOC,SOD) in the population of excess heat “shanghuo”. Methods:Excess heat “shanghuo” and normal population samples were collected, and the levels of MDA, GSH, SOD and T-AOC in plasma and ROS in peripheral blood leukocytes were detected and compared respectively. Results:The levels of MDA, GSH, SOD and T-AOC in the blood plasma of excess heat “shanghuo” were higher than those in the normal group (P<0.05), and the levels of ROS in leukocytes decreased significantly (P<0.01). Conclusion:The excess oxidation index (MDA) and antioxidant index (GSH, SOD, T-AOC) were all increased in excess heat “shanghuo” people, and the levels of ROS in leukocytes decreased significantly, indicating that excess heat “shanghuo” is closely related to oxidative stress; the organism is in a level state of oxidation and antioxidation, but the oxidation and antioxidant levels are in balance. |
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