世界中医药

目的:探究全蝎解毒汤联合化疗治疗急性白血病的临床疗效,分析其对患者血常规的影响。方法:选取87例于本院住院治疗的急性白血病初诊患者,随机分为对照组(n=44)及观察组(n=43),对照组患者给予标准化疗方案治疗,观察组患者在对照组治疗的基础上联合全蝎解毒汤治疗,30 d为1个疗程,2组均于治疗6个月后进行疗效评估。统计并比较2组临床疗效;检测并比较2组患者治疗前后髓外浸润症状改善情况及患者血常规变化。结果:治疗6个月后,观察组总缓解率为90.70%,较对照组的72.73%显著升高(P<0.05);治疗后观察组淋巴结肿大、肝脾肿大消失患者比例及改善率均显著高于对照组(P<0.05或P<0.01);与治疗前比较,治疗3、6个月后2组WBC、PLT均显著降低,且观察组WBC显著低于对照组,PLT显著高于对照组(P<0.01);2组RBC均显著升高,且观察组显著高于对照组(P<0.01);与治疗前比较,治疗3、6个月后对照组Hb显著降低(P<0.01),而观察组治疗6个月后显著升高(P<0.05),且治疗后观察组均显著高于对照组(P<0.05或P<0.01)。结论:全蝎解毒汤联合化疗可有效改善急性白血病患者髓外浸润症状及血常规,明显提高其临床疗效,显著优于常规化疗。

English Summary:

To explore the clinical efficacy of Quanxie jiedu decoction combined with chemotherapy in the treatment of acute leukemia, and analyze the effect on the blood routine examination. Methods:A total of 87 cases of acute leukemia patients who firstly visited in our hospital from September 2015 to November 2016 were selected and randomly divided into control group (n＝44) and treatment group (n＝43). The control group was treated with standard chemotherapy regimens, and treatment group was treated with Quanxie jiedu decoction on the basis of control group. The treatment for 30 days was one course. The clinical efficacy of 2 groups 6 months after treatment was evaluated. The clinical efficacy was recorded and compared. The improvement of marrow infiltration condition of 2 groups before and after treatment and the changes of blood routine examination were measured and compared. Results:The total response rate of treatment group 6 months after treatment was 90.70%, which was significantly higher than 72.73% of control group (P<0.05); The proportion of patients with lymphadenectasis and hepatosplenomegaly disappeared and the improvement rate in treatment group were higher than that in control group (P<0.05 or P<0.01); Compared with before treatment, the WBC, PLT decreased significantly in 2 groups 3 and 6 months after treatment, and the WBC of treatment group was lower than that of control group. The PLT of treatment group was higher than that of control group (P<0.01); the RBC of 2 groups increased significantly, and treatment group was higher than control group (P<0.01); compared with before treatment, the Hb of control group 3 and 6 months after treatment decreased significantly (P<0.01), and the treatment group increased significantly 6 months after treatment (P<0.05). The treatment group was higher than control group after treatment (P<0.05 or P<0.01). Conclusion:Quanxie jiedu decoction combined with chemotherapy can improve the marrow infiltration condition and blood routine examination of acute leukemia effectively, enhance the clinical efficacy, and which is better than conventional chemotherapy.

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