To explore the clinical effects of traditional Chinese medicine combined with non-invasive ventilation in patients with acute exacerbation of chronic pulmonary heart disease. Methods:A total of 82 cases of elderly chronic pulmonary heart disease who were treated in our hospital from January 2014 to December 2016 were selected and divided into control group and observation group according to the random number table method, with 41 cases in each group. The treatment methods of the control group were anti-inflammatory, oxygen-absorbing, anti-phlegm breathing, strong heart and non-invasive ventilation. The observation group was treated on the basis of the control group, combined with the treatment of pseudo formulae (prescription:Herba Ephedrae 10 g, Semen Armeniacae Amarum 15 g, Bulbus Fritillariae Thunbergii 15 g, Perillae Fructus 15 g, Fructus Trichosanthis 30 g, Cortex Mori 15 g, Semen Persicae 15 g, Radix Salviae Miltiorrhizae 15 g, Poria 15 g, Semen Plantaginis 15 g, Lumbricus 15 g, Herba Leonuri 30 g, Radix Glycyrrhizae 6 g). The clinical treatment effects, arterial blood gas index, pulmonary arterial pressure and cardiac output were compared. Results:After treatment, the total effective rate of observation group was higher than that of the control group. The primary symptoms, secondary symptoms, signs and CAT integrals of the observation group were significantly lower than that of the control group. The levels of PaO2, PEF and FEV1 of observation group were higher than those in the control group, and the level of PaCO2 was lower than that in the control group. The average pressure of the artery decreased, and the increase of cardiac output was better than that of the control group (P<0.05). Conclusion:The clinical curative effect of traditional Chinese medicine prescription combined with conventional treatment and non-invasive ventilation for the treatment of elderly patients with chronic pulmonary heart disease in acute exacerbation is remarkable and distinct, which can improve lung function of patients, reduce the average pulmonary artery pressure, increase cardiac output, and it is worthy of popularization and application in clinic.