| 引用本文:单其其格1，关敬之2，韩晓江3.加味参芪寿胎汤治疗早期先兆流产合并亚临床甲减的临床疗效及其对外周血中HMGB1、RAGE细胞因子的影响[J].世界中医药,2017,(12):. |
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| 加味参芪寿胎汤治疗早期先兆流产合并亚临床甲减的临床疗效及其对外周血中HMGB1、RAGE细胞因子的影响 |
| Curative Effect of Shenqi Shoutai Prescription in the Treatment of Early Phase Threatened Abortion Combined with Subclinical Hypothyroidism and its Effect on Cytokines of HMGB1 and RAGE in Peripheral Blood |
| 投稿时间：2017-01-18 |
| DOI：10.3969/j.issn.1673-7202.2017.12.023 |
| 中文关键词: 早期先兆流产 亚临床甲减 加味参芪寿胎汤 高迁移率族蛋白B1 晚期糖基化终末产物受体 |
| English Keywords:Early phase threatened abortion Subclinical hypothyroidism Shenqi Shoutai prescription HMGB1 RAGE |
| 基金项目:内蒙古医科大学青年创新基金项目（YKD2014QNCX029） |
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| 中文摘要: |
| 目的：探究加味参芪寿胎汤联合优甲乐治疗治疗早期先兆流产合并亚临床甲减的临床疗效及其对外周血中高迁移率族蛋白B1（High Mobility Group Box 1 Protein，HMGB1）、晚期糖基化终末产物受体(Receptor for Advanced Glycationend Product，RAGE）的影响。方法：选取2015年3月到2016年3月收治患早期先兆流产合并亚临床甲减及符合本研究标准的患者78例作为观察对象，按照随机数字表法分为观察组和对照组，每组39例。观察组给予加味参芪寿胎汤联合优甲乐治疗，对照组给予黄体酮注射液及优甲乐治疗。观察2组患者治疗前后血清β-人绒毛膜促性腺激素、雌二醇、孕酮、促甲状腺激素及外周血HMGB1及RAGE水平变化。结果：治疗后观察组HMGB1、RAGE阳性反应率优于对照组，差异有统计学意义（P<0.05），观察组总有效率为84.62%优于对照组69.23%，组间比较，差异有统计学意义（P<0.05），治疗后观察组血清β-人绒毛膜促性腺激素（β-human Chorionic Gonadotrophin，β-HCG）、雌二醇(Estradiol2,E2)、孕酮（Progesterone，P）及促甲状腺激素（Thyroid Stimulating Hormone，TSH）指数优于对照组,差异有统计学意义（P<0.05）。结论：加味参芪寿胎汤联合优甲乐治疗早期先兆流产合并亚临床甲减具有显著临床效果，可帮助患者改善临床症状，维持患者黄体，恢复正常妊娠水平，降低促甲状腺激素分泌，改善甲状腺功能，降低外周血中HMGB1、RAGE细胞因子指数，帮助机体内该炎性介质因子的分泌，增强机体免疫能力，充分调节机体内体液和细胞免疫，促使机体免疫状态相对平稳。 |
| English Summary: |
| To observe the curative effect of Shenqi Shoutai prescription combined with euthyrox in treatment of the early phase threatened abortion with subclinical hypothyroidism and its effect on cytokines of HMGB1 and RAGE in peripheral blood.Methods:A total of 78 cases of patients with early threatened abortion with subclinical hypothyroidism admitted into our hospital from March 2015 to March 2016 meeting the requirement of the research were selected.Then divided into study group and control group with 39 cases in each group.The study group was given Shenqi Shoutai prescription combined with euthyrox for treatment; and the control group was given progesterone Injection and euthyrox for treatment.The level changes of serum β-human chorionic gonadotropin,estradiol,progesterone,TSH and peripheral hematoma HMGB1 and RAGE for patients in two groups were compared.Results:After treatment,the positive rate of high mobility group protein B1 (high mobility group box 1 protein,HMGB1),advanced glycation end products (receptor for advanced glycationend product receptor,RAGE) was superior to those of the control group and the comparison was of statistical significance (P<0.05).The total efficiency of the study group was 84.62%,which was higher than the 69.23% in the control group.The difference was of statistical significance (P<0.05).After treatment,the index of serum beta human chorionic gonadotropin (beta-Human chorionic gonadotrophin,P-HCG),estradiol (Estradiol2,E2),progesterone (Progesterone,P) and thyroid stimulating hormone (Thyroid stimulating,hormone,TSH) was better than that of the control group.The comparison was of statistical significance (P<0.05).Conclusion:Shenqi Shoutai Prescription combined with euthyrox in the treatment of early threatened abortion with subclinical hypothyroidism has significant clinical effect.It can help patients to improve clinical symptoms,maintain patients' corpus luteum,recover to normal gestation level,reduce thyroid hormone secretion,improve thyroid function,reduce the cytokines indexes of HMGB1 and RAGE in peripheral blood,help the inflammatory medium secretion in the body,enhance immune capacity,fully regulate the body fluid and cellular immunity,and promote the relative balance of body immune state. |
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