To observe the clinical curative effect of Xingnao Yizhi Fang combined with rehabilitation training in the treatment of atonic cerebral palsy, and to analyze its mechanism. Methods:A total of 120 cases of children with cerebral palsy due to dystonia aging 2-6 years old who were treated in outpatient department and hospitalization department in our hospital from January 2014 to December 2015 were selected and divided into treatment group and rehabilitation group with 60 cases in each. And 20 cases of healthy children from physical examination department of our hospital were selected as control group. The rehabilitation group was given rehabilitation training, and the treatment group was given rehabilitation training combined with Xingnao Yizhi decoction. At the same time, the GMFM scale of each group was evaluated, and the changes of muscle strength were measured. The blood samples were taken to determine TGF-beta 1 and BDNF. The statistical difference of each group's data was analyzed and the clinical efficacy was also analyzed. Results:After treatment, GMFM, muscle strength and TGF-beta 1 were of the treatment group and rehabilitation group after treatment were significantly increased (P<0.05), and BDNF was decreased (P<0.05). There was no statistically significant difference between treatment group and control group after treatment (P>0.05). Conclusion:Xingnao Yizhi Fang combined with rehabilitation training can effectively improve the clinical symptoms of patients with low tension cerebral palsy, improve the muscle strength and the living ability of children, so it is worth popularizing.