世界中医药

目的:探讨六郁汤对奥氮平致精神分裂症患者代谢综合征的改善作用。方法:选取2015年1月至2017年1月恩施州精神卫生中心收治的精神分裂症合并代谢综合征患者120例,随机分为观察组与对照组,每组60例,观察组采用奥氮平联合六郁汤治疗,对照组给予奥氮平治疗,2组均治疗12周。比较2组患者临床疗效;比较治疗前后2组患者糖脂代谢指标、体重指数、血压变化;比较2组患者精神症状改善情况;统计2组患者治疗期间不良反应发生情况。结果:治疗后观察组的总有效率(93.33%),显著高于对照组(71.67%)(P<0.01);与治疗前比较,观察组血清FPG、HbAlc、TG水平及BMI均降低,且低于对照组(P<0.05或P<0.01);观察组血清HDL水平升高,且高于对照组(P<0.01),治疗后观察组DBP、SBP均较治疗前降低,且低于对照组(P<0.05或P<0.01),治疗后2组患者PANSS评分及观察组TESS评分均较治疗前下降,且观察组低于对照组(P<0.05或P<0.01)。结论:六郁汤可有效改善奥氮平致精神分裂症代谢综合征患者糖脂代谢,有效调节患者血压,并改善其精神症状,安全性良好。

English Summary:

To explore the improvement effects of Liuyu Decoction on olanzapine-induced metabolism syndrome of schizophrenic patients. Methods:A total of 120 cases schizophrenic with metabolic syndrome patients were selected and randomly divided into observation group (n＝60) and control group (n＝60). The observation group was treated with Liuyu Decoction and olanzapine, and the control group was treated with olanzapine. Both groups were treated for 12 weeks. The clinical efficacy of 2 groups was compared, and the changes of the glucose and lipid metabolism, body mass index, blood press of 2 groups before and after treatment were compared; The improvement of psychiatric symptoms of 2 groups was compared; The adverse reactions of 2 groups during the treatment were recorded. Results:The total effective rate of observation group (93.33%) was higher than control group (71.67%) (P<0.01); Compared with before treatment, the levels of serum FPG, HbAlc, TG and BMI of observation group decreased after treatment, and which were lower than control group (P<0.05 or P<0.01); The serum HDL of observation group after treatment increased than that before treatment, and which was higher than control group (P<0.01). The DBP and SBP of observation group after treatment decreased than that before treatment, and which were lower than control group (P<0.05 or P<0.01). The scores of PANSS and TESS of 2 groups after treatment decreased than that before treatment, and observation group was lower than control group (P<0.05 or P<0.01). Conclusion:Liuyu Decoction can effectively improve the glucose and lipid metabolism of olanzapine-induced metabolism syndrome of schizophrenic patients, effectively regulate the blood press of patients and improve the psychiatric symptoms with good safety.

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