世界中医药

目的:探究清热利湿祛瘀法治疗慢性前列腺炎的临床疗效,分析其对患者局部免疫功能的影响。方法:选取2017年1月至2017年6月南京中医药大学附属医院收治的慢性前列腺炎患者228例,按随机数字表法分为对照组和观察组,每组114例,2组患者均进行常规西药治疗,观察组在对照组治疗的基础上联合清热利湿祛瘀汤治疗,2组均以14 d为1个疗程,连续治疗3个疗程。治疗后统计2组临床疗效,评价2组治疗前后临床症状改善情况;分别于治疗前后检测并比较2组患者前列腺液中WBC及免疫指标的变化。结果:治疗后观察组临床总有效率高达93.86%,较对照组的73.68%显著升高(P<0.01);与治疗前比较,治疗后2组患者IIEF评分明显升高,且观察组显著高于对照组(P<0.01);2组患者NIH-CPSI评分及QOL评分明显降低,且观察组显著低于对照组(P<0.01);与治疗前比较,治疗后2组患者前列腺液WBC均明显降低(P<0.05或P<0.01),且观察组显著低于对照组(P<0.05);与治疗前比较,治疗后观察组前列腺液中SIgA及IgG含量均显著降低,且显著低于对照组(P<0.01)。结论:清热利湿祛瘀法可显著改善慢性前列腺患者临床症状,抑制其局部炎性反应,并可有效降低其前列腺液中免疫球蛋白含量,调节局部免疫应答,疗效显著优于常规西药治疗。

English Summary:

To explore the clinical efficacy of Qingrelishi Quyu method in the treatment of chronic prostatitis patients and the effect on local immune function. Methods:A total of 228 chronic prostatitis patients who were treated in our hospital from January 2017 to June 2017 were selected and randomly divided into control group (n＝114) and experiment group (n＝114). Control group were treated with conventional western medicine treatment, and experiment group were treated with Qingrelishi Quyu decoction on the basis of control group. 14 d were 1 treatment course, and 2 groups were treated for 3 courses continuously. The clinical efficacy of 2 groups was counted and the improvement of clinical symptoms before and after treatment in 2 groups was evaluated. Additionally, the WBC and immune indexes of prostatic fluid in 2 groups before and after treatment were detected and compared. Results:The total effective rate of experiment group reached up to 93.86% after treatment, which was higher than that 73.68% of control group (P<0.01); Compared with the score before treatment, the IIEF score of 2 groups increased significantly after treatment, and experiment group was higher than control group (P<0.01); the NIH-CPSI and QOL scores of 2 group decreased significantly after treatment, and experiment group was lower than control group (P<0.01); Compared with the one before treatment, the WBC of prostatic fluid in 2 groups decreased significantly after treatment (P<0.05 or P<0.01), and experiment group was lower than control goup (P<0.05); Compared with the level before treatment, the SIgA and IgG levels of prostatic fluid in experiment group decreased significantly after treatment, and which were lower than that of control group (P<0.01). Conclusion:Qingrelishi Quyu method can improve the clinical symptoms of chronic prostatitis patients significantly, inhibit the local inflammatory response, reduce the immune globulin level of prostatic fluid, and adjust the local immune response. The clinical efficacy is superior to conventional western medicine.

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