世界中医药

目的:研究芝麻木酚素(SL)对肾型高血压大鼠的降压作用及降压机制。方法:选择雄性SD大鼠作为实验动物,随机分为假手术组、模型组和SL组,建立肾型高血压大鼠模型并给予10 mg/kg/d芝麻木酚素干预。干预后,测定血压水平及氧化应激反应、血管内皮功能。结果:干预后3周、4周、5周、6周时,模型组大鼠的MBP水平均显著高于假手术组,SL组大鼠的MBP水平显著低于模型组;干预后6周时,模型组大鼠肾脏中MDA、AOPP的含量以及血清中MDA、AOPP、ET-1的含量显著高于假手术组,肾脏中SOD、GSH-Px的含量以及血清中SOD、GSH-Px、NO的含量显著低于假手术组;SL组大鼠肾脏中MDA、AOPP的含量以及血清中MDA、AOPP、ET-1的含量显著低于模型组;肾脏中SOD、GSH-Px的含量以及血清中SOD、GSH-Px、NO的含量显著高于模型组。结论:芝麻木酚素能够通过抑制氧化应激反应、减轻血管内皮损伤的机制来降低肾型高血压大鼠的血压水平。

English Summary:

To study the antihypertensive effect and mechanism of Sesame Lignan (SL) on renal hypertensive rats.Methods:Male SD rats were selected as experimental animal and randomly divided into sham surgery group, model group and SL group.The model of renovascular hypertensive rats was established and given 10 mg/kg/d Sesame Lignan for intervention.After intervention, blood pressurelevels, oxidative stress and endothelial function were measured.Results:In 3 weeks, 4 weeks, 5 weeks and 6 weeks after intervention, MBP levels of model group were significantly higher than sham surgery group.MBP levels of SL group were significantly lower than model group; 6 weeks after intervention, AOPP, MDA contents in kidney and AOPP, MDA,ET-1 contents in serum of model group were significantly higher than sham surgery group.SOD, GSH-Px contents in kidney and SOD, GSH-Px, NO contents in serum were significantly lower than sham surgery group; AOPP, MDA contents in kidney and AOPP, MDA, ET-1 contents in serum of LS group were significantly lower than model group.SOD, GSH-Px contents in kidney and SOD, GSH-Px, NO contents in serum were significantly higher than model group.Conclusion:Sesame Lignancan reduces blood pressure level of renal hypertensive rats by inhibiting oxidative stress and reducing vascular endothelium damage.

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