| 引用本文:杨春，唐阳.左归补髓生血汤治疗小儿急性白血病白细胞减少症的疗效及对血清可溶性细胞间黏附分子-1和转化生长因子-β1的影响[J].世界中医药,2018,(01):. |
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| 左归补髓生血汤治疗小儿急性白血病白细胞减少症的疗效及对血清可溶性细胞间黏附分子-1和转化生长因子-β1的影响 |
| Study on Clinical Effects of Zuogui Busui Shengxue Decoction in the Treatment of Leukopenia in Children with Acute Leukemia and Effects on Serum sICAM-1 and TGF-β1 |
| 投稿时间：2017-08-22 |
| DOI：10.3969/j.issn.1673-7202.2018.01.012 |
| 中文关键词: 左归补髓生血汤 白血病 白细胞减少症 可溶性细胞间黏附分子-1 转化生长因子-β1 疗效 |
| English Keywords:Zuogui Busui Shengxue Decoction Leukemia Leukopenia Soluble intercellular adhesion molecule-1 Transforming growth factor-β1 Efficacy |
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| 中文摘要: |
| 目的：探讨左归补髓生血汤治疗小儿急性白血病白细胞减少症的疗效及对血清可溶性细胞间黏附分子-1（sICAM-1）、转化生长因子-β1（TGF-β1）的影响。方法：选取2015年1月至2017年1月进行化疗的急性白血病患儿120例，均存在化疗后白细胞减少症，将其随机分为对照组及观察组，各60例。2组患儿均给予鲨肝醇片50 mg/次，维生素B4片，20 mg/次，2次/d，观察组给予左归补髓生血汤治疗，2组均连续服用14 d。于治疗前及治疗后3 d、7 d、14 d、21 d检测并记录2组患儿白细胞及中性粒细胞计数，统计2组临床疗效及治疗期间患儿感染情况，检测并比较2组治疗前后血清sICAM-1、TGF-β1水平的变化。结果：观察组临床总有效率为83.33%，显著高于对照组的53.33%（P<0.05）。治疗期间观察组发生感染13例，平均抗生素使用时间（7.01±2.34）d；对照组发生感染28例，平均抗生素使用时间（13.42±4.67）d；2组间感染发生率及抗生素使用时间差异有统计学意义（P<0.05）。与治疗前比较，治疗后3~21 d 2组患儿白细胞及中性粒细胞计数呈逐渐升高趋势（P<0.05），且治疗后观察组白细胞及中性粒细胞计数均高于对照组（P<0.05或P<0.05）。与治疗前比较，治疗后2组患儿血清中sICAM-1明显降低，且观察组低于对照组（P<0.05），TGF-β1水平明显升高，且观察组高于对照组（P<0.05）。结论：左归补髓生血汤联合常规方法治疗小儿急性白血病化疗后白细胞减少症效果显著，可有效增加外周血白细胞及中性粒细胞数量，可能与其能够调节血清中sICAM-1、TGF-β1水平有关。 |
| English Summary: |
| To investigate the effects of Zuogui Busui Shengxue Decoction in the treatment of leukopenia in children with acute leukemia and effects on serum soluble intercellular adhesion molecule-1 (sICAM-1) and transforming growth factor-β1 (TGF-β1). Methods:A total of 120 children with acute leukemia who had received chemotherapy in Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from January 2015 to January 2017 were selected and diagnosed leukopenia after chemotherapy. They were randomly divided into the control group and the experiment group, 60 cases in each group. Children of the 2 groups were given Batilol Tablets 50 mg, bid, and vitamin B4 tablets 20 mg, bid. In addition, the experiment group was given Zuogui Busui Shengxue Decoction, and 2 groups of patients were given continuous treatment for 14 days. The levels of all the patients' white blood cells and neutrophils were tested and recorded before treatment and in the 3rd day, the 7th day, the 14th day and the 21st day after treatment, the clinical efficacy of the 2 groups and the infection of the children during the treatment were counted. The changes of levels of serum sICAM-1 and TGF-β1 were detected before and after treatment. Results: The clinical total effective rate of the experiment group was 83.33%, which was significantly higher than 53.33% of the control group (P<0.05). During the treatment, the experiment group had 13 cases of infection, and the time of antibiotic use was (7.01±2.34) days; the control group had 28 cases of infection, and the time of antibiotic use was (13.42±4.67) days; the incidence of infection and antibiotic use time had significant difference between the 2 groups (P<0.05). Compared with the situation before treatment, 3rd~21st days after treatment the white blood cell and neutrophil counts of the 2 groups increased gradually (P<0.05), and the experiment group was higher than those of the control group (P<0.05 or P<0.05). Compared with the situation before treatment, sICAM-1 in serum of the 2 groups significantly decreased, and the experimental group was lower than that of the control group (P<0.05); the level of TGF-β1 significantly increased higher in the experiment group than in the control group (P<0.05). Conclusion: Zuogui Busui Shengxue Decoction combined with conventional method has remarkable effects, which can significantly increase the white blood cell and neutrophil count in peripheral blood leukemia after chemotherapy. It may be related to its ability to regulate serum levels of sICAM-1 and TGF-β1. |
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