世界中医药

目的：探讨小剂量腹膜透析联合参苓白术颗粒治疗尿毒症患者的临床疗效。方法：选取2014年5月至2017年5月盘锦市中心医院收治的腹膜透析的尿毒症患者64例，按照随机表法，分为中药组和对照组各32例。中药组采用小剂量腹膜透析联合参苓白术颗粒治疗，对照组采用常规腹膜透析法,疗程均为6个月，比较2组中医症状改善情况、血红蛋白(Hb)、白蛋白(Alb)、总蛋白（TP）、尿素氮(BUN)、血肌酐（Scr）等生化指标，记录尿量，计算腹膜透析尿素清除指数（KT/V）。结果：中药组治疗后中医症状改善情况优于对照组，差异有统计学意义（P<0.05）；中药组治疗后与对照组治疗后的BUN、Scr比较差异无统计学意义（P>0.05），中药组治疗Hb、Alb、TP、尿量均明显高于对照组治疗后，差异有统计学意义（P<0.01）；中药组治疗后与对照组治疗后的残肾KT/V比较差异无统计学意义（P>0.05），腹膜KT/V明显高于对照组治疗后，差异有统计学意义（P<0.01）；中药组治疗后生命质量评估明显高于对照组治疗后，差异有统计学意义（P<0.05）；中药组治疗后体质量指数(BMI)、三头肌皮皱厚度(TSF)明显高于对照组治疗后，差异有统计学意义（P<0.05）。结论：小剂量腹膜透析法联合参苓白术颗粒不仅可以降低治疗成本，提高患者部分生化指标，又能改善患者临床症状，优化患者生命质量和营养状况，值得推广。

English Summary:

To investigate the clinical curative effect of small dose of peritoneal dialysis combined with Shenling Baizhu Granules in treatment of uremic patients. Methods: A total of 64 patients with peritoneal uremia were admitted and treated in Panjin Central Hospital of Liaoning Province from May 2014 to May 2017 and randomly divided into Chinese medicine group and control group according to random table method, with 32 cases in each group. The patients in Chinese medicine group were treated with small dose of peritoneal dialysis combined with Shenling Baizhu Granules, and those in control group were treated with conventional peritoneal dialysis, continuous treatment for 6 months. The biochemical indexes of two groups including TCM symptoms, hemoglobin (Hb), albumin (Alb), total protein (TP), urea nitrogen (BUN) and serum creatinine (Scr) were compared, and the amount of urine was recorded. The peritoneal dialysisurea clearance index (KT/V) was caculated. Results: The improvement of TCM symptoms in Chinese medicine group was significantly better than that in control group, and the difference was statistically significant (P<0.05); There were no significant differences of BUN and Scr in Chinese medicine group before and after treatment (P>0.05). After treatment, the indexes of Hb, Alb, TP and urine volume in Chinese medicine group were significantly higher than those in control group, and the differences were statistically significant (P<0.01); After treatment, there was no significant difference in KT/V between Chinese medicine group and control group (P>0.05), and the peritoneal KT/V was significantly higher than that in the control group, and the difference was statistically significant (P<0.01); After treatment, the quality of life in Chinese medicine group was significantly higher than that in control group, and the difference was statistically significant (P<0.05); Body mass index (BMI) and triceps skinfold thickness (TSF) in Chinese medicine group were significantly higher than those in control group after treatment, and the differences were statistically significant (P<0.05). Conclusion: Small dose of peritoneal dialysis combined with Shenling Baizhu Granules can not only reduce the cost of treatment, improve the biochemical indexes of patients, and improve the symptoms of patients, optimize the quality of life and the nutritional status of patients, which is worthy of promotion.

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