| 引用本文:司海鹏1，朱长乐1，秦菲2，叶柏3.中药经验方治疗溃疡性结肠炎不同时期TNF-α及IL-23的变化[J].世界中医药,2018,(01):. |
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| 中药经验方治疗溃疡性结肠炎不同时期TNF-α及IL-23的变化 |
| Changes of IL-23 and TNF-α in Different Stages of Ulcerative Colitis Treated by Chinese Materia Medica Empirical Formula |
| 投稿时间：2016-05-24 |
| DOI：10.3969/j.issn.1673-7202.2018.01.018 |
| 中文关键词: 溃疡性结肠炎 IL-23 TNF-α 免疫组化 |
| English Keywords:Ulcerative colitis IL-23 TNF-α Immunohistochemistry |
| 基金项目:国家自然科学基金青年项目（81403344）——“黄芩苷干预PI3K/AKT/NF-κB信号通路对溃疡性结肠炎免疫调节、肠黏膜屏障修复的作用机制研究”；国家中医药行业科研专项资助(201407001）——“针对难治性脾胃病的中医药诊疗规范转化应用研究” |
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| 中文摘要: |
| 目的：探讨溃疡性结肠炎（Ulcerative Colitis，UC）患者在中药经验方治疗不同时期TNF-α及IL-23的变化。方法：选取2011年4月至2014年8月在南京中医药大学附属医院经中医辨证后诊断为UC的患者26例，作为观察组，取健康志愿者26例作为正常对照。观察组给予中药经验方治疗，分别在疾病活动期和缓解期内镜下取活检，用免疫组化方法检测组织中TNF-α及IL-23表达。结果：各组TNF-α及IL-23表达显示，UC活动期与缓解期组比较，及UC活动期与正常组比较，差异有统计学意义（P<0.05）,而UC缓解期与正常组比较，差异无统计学意义（P>0.05）。结论：经验方可以降低溃疡性结肠炎患者活动期组织中细胞因子水平，从而抑制其对黏膜的损伤。 |
| English Summary: |
| To explore the changes of IL-23 and TNF-α in different stages of the patients with ulcerative colitis (UC) treated with Chinese materia medica empirical formula. Methods:A total of 26 patients who were diagnosed as UC through TCM syndrome differentiation in Affiliated Hospital of Nanjing University of TCM from April 2011 to August 2014, were treated with Chinese materia medica empirical formula. Biopsy was performed during active stage and remission stage. The expression of IL-23 and TNF-α in the intestina1 mucosa in different stages were assessed by immunohistochemistry (IHC). Another 26 healthy volunteers were selected as control. Results:The expression levels of IL-23 and TNF-αin active stage were higher than those of the control group and those in remission stage with statistically significant differences (P<0.05). There was no statistically significant difference in UC remission stage when compared with control group. Conclusion:Chinese materia medica empirical formula could reduce the inflammatory reaction of UC patients in active stage, so as to inhibit damage to intestina1 mucosa. |
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