| 引用本文:姚乐，熊肇明.中西医结合治疗急性结石性胆囊炎患者的临床疗效及对患者血凝的影响[J].世界中医药,2018,(01):. |
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| 中西医结合治疗急性结石性胆囊炎患者的临床疗效及对患者血凝的影响 |
| Clinical Effects of Traditional Chinese Medicine Combined with Western Medicine in the Treatment of Patients with Acute Calculous Cholecystitis and Effcts on Blood Coagulation Yao Le, Xiong Zhaoming |
| 投稿时间：2017-08-29 |
| DOI：10.3969/j.issn.1673-7202.2018.01.019 |
| 中文关键词: 中西医结合 急性结石性胆囊炎 疗效 血凝 |
| English Keywords:Chinese and western medicine Acute calculous cholecystitis Curative effect Blood coagulation index |
| 基金项目:上海科学技术委员会科研计划项目（124119a3202） |
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| 中文摘要: |
| 目的：探讨中西医结合治疗急性结石性胆囊炎患的疗效及对患者血凝的影响。方法:选取86例急性结石性胆囊炎患者，按照随机表法将分为观察组与对照组，各43例。2组患者均于入院后进行腹腔镜胆囊切除术治疗。对照组于术后给予抗感染、纠正酸碱平衡、纠正水电解质紊乱、胃肠减压及消炎利胆等治疗；观察组在对照组基础上联合中药汤剂治疗。2组疗程均为7 d。比较2组的疗效，治疗前后血凝指标和炎性因子变化，及腹痛缓解时间和白细胞恢复时间。结果：观察组治疗总有效率（95.35%）高于对照组（76.74%）（P<0.05）。2组治疗后凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）增加（P<0.05）；观察组治疗后PT和APTT高于对照组（P<0.05）。2组治疗后白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平降低（P<0.05）；观察组治疗后IL-6和TNF-α水平低于对照组（P<0.05）。观察组腹痛缓解时间和白细胞恢复时间快于对照组（P<0.05）。结论：中西医结合治疗急性结石性胆囊炎患者临床疗效明显，且可改善患者血凝状态。 |
| English Summary: |
| To investigate the clinical efficacy of traditional Chinese medicine combined with western medicine in the treatment of acute calculous cholecystitis and its effects on blood coagulation. Methods: A total of 86 patients with acute calculous cholecystitis were admitted and treated in Shanghai Tenth People's Hospital from July 2016 to July 2017 and were randomly divided into the observation group (43 cases) and the control group (43 cases). Two groups of patients were treated with laparoscopic cholecystectomy after admission. The patients in the control group were given anti-infection, correcting acid-base balance, correcting water and electrolyte disturbance, gastrointestinal decompression and anti-inflammatory and cholagogic treatment after operation. The observation group was treated with Chinese medicine decoction on the basis of the therapies in the control group. Both of the two groups were treated for 7 days. The therapeutic effects, the changes of blood coagulation indexes and inflammatory factors, the time of abdominal pain relief and the recovery time of leukocytes were compared between the two groups. Results: The total effective rate of the observation group (95.35%) was higher than that of the control group (76.74%) (P<0.05). Prothrombin Time (PT) and activated partial thromboplastin time (APTT) increased in the two groups after treatment (P<0.05), and PT and APTT indexes in the observation group were higher than those in the control group (P<0.05). Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels decreased in two groups after treatment (P<0.05); and IL-6 and TNF-α levels in the observation group were lower than those in the control group after treatment (P<0.05). The relief time of abdominal pain and the recovery time of WBC in the observation group were faster than those in the control group (P<0.05). Conclusion: The clinical effect of the treatment of acute calculous cholecystitis with traditional Chinese medicine combined with western medicine is significant and it can improve the blood coagulation status of patients, which has important research significance. |
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