| 引用本文:沈玉国1，叶婷2.消瘿散结方联合左旋甲状腺素片治疗良性甲状腺结节的临床疗效及安全性[J].世界中医药,2018,(01):. |
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| 消瘿散结方联合左旋甲状腺素片治疗良性甲状腺结节的临床疗效及安全性 |
| Observation on Clinical Efficacy Xiaoying Sanjie Fang Combined with Levothyroxine in the Treatment of Benign Thyroid Nodules and Evaluation on its Safety |
| 投稿时间：2017-03-06 |
| DOI：10.3969/j.issn.1673-7202.2018.01.023 |
| 中文关键词: 消瘿散结方 左旋甲状腺素片 良性甲状腺结节 临床疗效 不良反应 |
| English Keywords:Xiaoying Sanjie Decoction Levothyroxine Benign thyroid nodules Clinical efficacy Adverse toxic reaction |
| 基金项目:新疆卫生厅青年科技人才专项科研项目(2013Y24) |
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| 中文摘要: |
| 目的：探究消瘿散结方联合左旋甲状腺素片治疗良性甲状腺结节的疗效以及安全性。方法：选取2014年6月至2016年6月新疆医科大学附属中医医院收治的良性甲状腺结节患者125例，对其临床资料进行回顾性分析。根据用药方案中是否使用消瘿散结方分成观察组和对照组，其中观察组为62例，对照组为63例。进行6个月治疗后，比较2组患者治疗后的疗效、甲状腺结节大小变化以及不良反应等。结果：与治疗前比较，观察组和对照组的甲状腺结节最长径、体积和甲状腺功能血清学指标（TSH）均明显下降，且差异有统计学意义。与对照组比较，观察组总有效率更高（82.26%比50.79%）；甲状腺结节最长径变化更大，（4.14±0.67）mm比(1.61±0.72）mm；体积缩小更明显，（2.74±0.91）mm比(1.16±0.59）mm；甲状腺功能血清学指标（TSH）下降更显著，（15.13±4.71）比(7.97±7.66）；不良反应发生率更低（11.29%比26.98%），差异均有统计学意义（P<0.05）。结论：消瘿散结方联合左旋甲状腺素片方案对于非手术治疗的甲状腺良性结节比单用左旋甲状腺素片更为有效，安全性更高。 |
| English Summary: |
| To investigate the clinical efficacy and safety of the treatment of benign thyroid nodules with Xiaoying Sanjie Decoction combined with levothyroxine. Methods:A total of 125 patients with benign thyroid nodules who were treated in Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University from June 2014 to June 2016 were selected, and the clinical data was analyzed retrospectively. According to different treatments, these patients were divided into study group with 62 cases (levothyroxine solutions combined with Xiaoying Sanjie Fang) and control group with 63 cases (levothyroxine solutions only). After 6 months of treatment, clinical data of curative effect, size of thyroid nodules and adverse toxic reaction of the two groups were compared and T-test and chi square test were applied. Results:The difference of the date of patients before treatment had no significant statistical difference (P?0.05). Compared with prior treatment, the longest diameter, volume and thyroid function of thyroid nodules (TSH) of the two groups were significantly decreased, and it had statistical significance. Compared with control group, overall efficiency of study group was more significant (82.26% vs 50.79%); The changes of longest diameter of thyroid nodules were more significant (4.14±0.67 vs 1.61±0.72 mm); volume reduction was more prominent (2.74±0.91 vs 1.16±0.59 mm); TSH decrease was more appreciable (15.13±4.71 vs 7.97±7.66); The incidence of adverse reaction was lower (11.29% vs 26.98%). Conclusion:Xiaoying Sanjie Decoction combined with levothyroxine solutions for non-surgical benign thyroid nodules is more effective with higher safety than single levothyroxine, and it is worthy for clinical application. |
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