| 引用本文:孙琛1，冯野1，谢培1，宋忠兴2，唐志书1.沙棘果渣总黄酮的降血脂及降血糖作用[J].世界中医药,2018,(01):. |
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| 沙棘果渣总黄酮的降血脂及降血糖作用 |
| Hypolipidemic and Hypoglycemic Effects of Total Flavonoids from Pomace of Fructus Hippophae |
| 投稿时间：2017-02-28 |
| DOI：10.3969/j.issn.1673-7202.2018.01.036 |
| 中文关键词: 沙棘果渣总黄酮 降血脂作用 降血糖作用 |
| English Keywords:Total flavonoids from pomace of Fructus Hippophae Hypolipidemic effects Hypoglycemic effects |
| 基金项目:陕西省科技厅社会发展科技攻关项目（2015SF244）——利用沙棘果渣开发沙酮降脂胶囊研究 |
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| 中文摘要: |
| 目的：探讨沙棘果渣总黄酮的降血脂及降血糖作用。方法：昆明种雄性小鼠72只适应环境7 d后，随机分成6组（n＝12）：空白对照组、模型组、辛伐他丁组，总黄酮小、中、高剂量组。除空白对照组外，其余各组喂高脂饲料诱发高血脂症，每天称小鼠体质量1次，按体质量更换给药剂量。试验第40天取血后解剖小鼠，检测TC、TG、HDL-C、LDL-C含量，观测体质量及脏器指数的变化情况。采用小鼠高血糖模型降糖实验方法考察沙棘果渣总黄酮的降血糖活性。结果：沙棘果渣总黄酮各剂量与模型组比较，可以显著降低TC、TG和LDL-C的含量（P<0.05），显著升高HDL-C的含量（P<0.05）；沙棘果渣总黄酮组空腹血糖值显著降低（P<0.05）。结论：沙棘果渣总黄酮具有降血脂及降血糖活性。 |
| English Summary: |
| To study the hypolipidemic and hypoglycemic effects of total flavonoids from pomace of Fructus Hippophae.Methods:A total of 72 Kunming male mice were randomly divided into six groups (n＝12 in each group):normal group, model group, simvastatin group, low-dose flavonoid group, middle-dose flavonoid group and high-dose flavonoid group.Except the blank control group, the mice were fed with high fat diets to induce hyperlipidemia.The body weight of mice was measured every day, and the dose was adjusted according to the weight.On the 40th day, the mice were decapitated and the TC, TG, HDL-C and LDL-C were detected.Changes of weight and viscera indexes were observed.The hypoglycemic activity of polysaccharide was investigated by animal experiments.Results:Compared with model group, the TC, TG and LDL-C of serum in the flavonoid groups were deceased significantly (P<0.05) and HDL-C was increased significantly (P<0.05).The total flavonoids from pomace of Fructus Hippophae group decreased fasting blood glucose values significantly (P<0.05).Conclusion:The total flavonoids from pomace of Fructus Hippophae have hypolipidemic and hypoglycemic effects. |
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