To observe the clinical effects of auricular-plaster therapy with seeds combined with precocity fang for precocious puberty girls. Methods:A randomized controlled clinical trial was used in this study, which was aimed to observe the clinical effects of auricular-plaster therapy with seeds combined with precocity fang for precocious puberty girls with the control of precocity fang. A total of 62 cases who were received in specialist outpatient of pediatrics department in our hospital from June 2014 to March 2016 were selected. 31children were given auricular-plaster therapy with seeds combined with precocity fang in the treatment group, and another 31children were given precocity fang in the control group. The treatment period was 3 months. The indexes of height, weight, symptoms, diameter of nodules in the breast, Tanner stage and TCM syndrome were observed before treatment, treatment for 1 month, 2 months, 3 months and 6 months. Uterine volume, ovarian volume, the level of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Estradiol (E2), Prolactin (PRL) and Alanine Transaminase (ALT), Blood Urea Nitrogen (BUN), Creatinine (Cr) were detected before treatment and treatment for 3 months, and the clinical effects were evaluated. The bone age was detected before treatment and treatment for 3 months. Results:1) The total effective rate was 100% in treatment group and 71% in control group with statistically significant difference (P<0.05). 2) The total effective rate for improving the TCM syndrome was 100% in treatment group and 100% in control group with statistically significant difference (P<0.001). 3) Within both of the groups, there was statistically significant difference in the height growth rate before and after treatment (P<0.001), and also statistically significant difference between the 2 groups (P<0.001). 4) Within both of the groups, there was statistically significant difference in the weight before and after treatment (P<0.05), and also statistically significant difference between the 2 groups (P<0.001). 5) Within both of the groups, there was no statistically significant difference in the uterine and ovarian volume before and after treatment (P>0.05), and also no statistically significant difference between the 2 groups (P>0.05). 6) Within both of the groups, there was no statistically significant difference in the level of LH, FSH, E2, PRL before and after treatment (P>0.05), and also no statistically significant difference between the 2 groups (P>0.05). 7) Within both of the groups, there was statistically significant difference in the bone age before and after treatment (P<0.05), and also statistically significant difference between the 2 groups (P<0.001). 8) Within both of the groups, there was statistically significant difference in the TCM syndrome grades before and after treatment (P<0.001), and also statistically significant difference between the 2 groups (P<0.001). 9) Within both of the groups, the levels of ALT, BUN, Cr before and after treatment were within normal range. Conclusion:The auricular-plaster therapy with seeds combined with precocity fang can effectively treat precocious puberty girls of phlegm-heat syndrome, and it can improve TCM syndrome grades, increase the height growth rate, control body weight, slow down the bone growth, but it has no significant influence on the level of LH, FSH, E2, PRL and uterine and ovarian volume. The clinical curative effect of auricular-plaster therapy with seeds combined with precocity fang is better than that of precocity fang.