| 引用本文:李志强1，刘凤新2，何玉霞3.穴位手法注射卷曲霉素与莫西沙星联合治疗耐多药肺结核的疗效观察[J].世界中医药,2018,(01):. |
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| 穴位手法注射卷曲霉素与莫西沙星联合治疗耐多药肺结核的疗效观察 |
| Observation on Curative Effect of Acupoint Injection Technique of Capreomycin Combined with Moxifloxacin in the Treatment of Multi Drug Resistant Pulmonary Tuberculosis |
| 投稿时间：2016-12-09 |
| DOI：10.3969/j.issn.1673-7202.2018.01.048 |
| 中文关键词: 卷曲霉素 莫西沙星 穴位手法注射 自觉好转率 病灶消化率 |
| English Keywords:Capreomycin Moxifloxacin Injection acupuncture point technique Consciously digestibility improvement rate |
| 基金项目:沧州市科学技术研究与发展指导计划项目（162302097）——穴位手法注射卷曲霉素与莫西沙星联合治疗耐多药肺结核的疗效观察 |
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| 中文摘要: |
| 目的：探讨穴位手法注射卷曲霉素联合莫西沙星治疗耐多药肺结核的近期及远期疗效。引入患者自觉好转率做为耐多药肺结核的疗效评判指标，观察与其他评判指标的一致性。方法：选取2012年3月至2014年3月医院收治耐多药肺结核患者108例，采用随机数字表法平均分为观察组和对照组，每组54例。观察组给予6CmMxPtoPaZ/18MxPtoPaZ,对照组给予6CmVPtoPaZ/18VPtoPaZ（Cm：卷曲霉素，Mx：莫西沙星片，Pto：丙硫异烟胺，Pa：对氨基杨酸钠，Z：吡嗪酰胺，V：左氧氟沙星片），其中Cm采用改良手法穴位注射，并均全程给予水飞蓟宾葡甲胺片保肝治疗。研究对照2组治疗过程中的疗效及不良反应。结果：经过治疗在6个月和24个月时，观察组的患者自觉好转率、病灶消化率、空洞愈合率均明显高于对照组，差异有统计学意义（P<0.05）。6个月时痰培养阴性率观察组明显高于对照组，差异有统计学意义（P<0.05），但24个月时痰培养阴性率2组无明显差别，χ2=1.87，差异无统计学意义（P>0.05）。观察组和对照组不良反应统计学上无明显差。6个月时χ2=1.92，差异无统计学意义（P>0.05），24个月时χ2=2.12，差异无统计学意义（P>0.05）。结论：通过改良手法穴位注射卷曲霉素联合莫西沙星治疗效果明显好于联合左氧氟沙星。虽然莫西沙星组费用较高，但治愈率高，在目前耐多药肺结核难治性前提下很值得临床推广应用。患者自觉好转率与其他疗效评判指标具有良好的一致性，可以用于疗效的判定。 |
| English Summary: |
| To investigate the curative effect of acupoint injection technique of capreomycin combined with moxifloxacin in the treatment of multi drug resistant pulmonary tuberculosis, and effects of moxifloxacin on patients' compliance.Methods:From March 2012 to March 2014, 108 patients with multi drug resistant pulmonary tuberculosis were selected and divided into the observation group and the control group by random number table method.The observation group was given 6CmMxPtoPaZ/18MxPtoPaZ, and the control group was given 6CmVPtoPaZ/18VPtoPaZ, which by the improved Cm technique and acupoint injection, were given a full course of treatment of liver Silibin Meglumine Tablets.The efficacy and adverse reactions of the two groups was studied.Results:After 6 months and 24 months after treatment, the patients' self improvement rate, the rate of lesion digestibility and cavity healing rate were significantly higher than those in the control group, and the difference was statistically significant (P<0.05).At 6 months after treatment, the sputum negative rate of observation group was significantly higher than that of the control group (P<0.05), but at 24 months the negative rate of sputum culture of two groups were not significantly different (χ2=1.87, P>0.05).There was no significant difference in adverse reaction between the observation group and the control group.Conclusion:The modified method of acupoint injection capreomycin combined with moxifloxacin in the treatment effect was better in combination with levofloxacin.Although the moxifloxacin group cost is higher, the cure rate is high.It is worthy of clinical application in treating multi drug resistant pulmonary tuberculosis.The self improvement rate and other assessment index of efficacy have good consistence, which can be used as determination of clinical effect. |
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