世界中医药

柴胡一药,又称“芘胡”,频繁出现于诸多方剂之中,颇受医者青睐,然而从诸多古籍文献中可以发现,柴胡应用虽多,但不同医家,所书不同专著、不同方剂中柴胡剂量的应用、作用的功效却不尽相同,相应炮制品的选用也各有差异。通过对此总结、分类,确立了柴胡的不同用量类别,确定了古今用量之间的关联,梳理了不同剂量发挥出的不同功效及其相应的应用,并以临床应用、实验药理佐证。从量效角度剖析柴胡,从而得出小剂量柴胡行升举阳气之功,中剂量行疏肝解郁、调畅气机之功,大剂量行和解少阳、解表退热之功,过量久服有“耗气伤阴”之嫌的结论。强调了量效关系的重要性,为更好地在临床中应用此味药提供依据与支撑。

English Summary:

Radix Bupleuri, which is also called “Pihu”, frequently appears in different prescriptions, and favored by doctors. However, it can be found from many ancient books and literatures that there are many applications of Radix Bupleuri, but the dosages and functions of Radix Bupleuri appeared in different literatures and prescriptions are not all the same. And the selection of drugs with different ways of processing is various. Through summarizing and classifying, the different groups of dosages and the relationship between ancient and modern dosage are established, and the functions of different dosages and their corresponding applications are reviewed, with clinical application and experimental pharmacology as evidence. It was studied from the view of dose-effect relationship of Radix Bupleuri, which has come to a conclusion that small dose of Radix Bupleuri has the effect of raising yang qi; middle dose of Radix Bupleuri has the effect of soothing the liver and resolving constraint, regulating qi movement; high dose of Radix Bupleuri has the effect of harmonizing shaoyang, clearing heat to release the exterior, and overdose and long-taken have the suspicion of “consuming qi and damaging yin”, which shows the importance of the relationship of dose-effect, and provides the basis and support for better use of this drug in clinic.

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