Miao Xiyong emphasized in Commentary on ‘Shen Nong's Classic of the Materia Medica' that “Tonification and purgation according to likes and dislikes of five viscera is the first principle of medication”, which has been valued by doctors of all dynasties. According to Plain Questions·Discussion on the Association of the Zang-qi with the Four Seasons, we reviewed the medication paradigm of Treatise on Febrile Diseases and Synopsis of Golden Chamber focused on the “five flavors regulate five viscera function in reinforcing and reducing” in order to inherit and develop Zhongjing's academic ideas, to inspire the thoughts of clinical prescription and medication to improve the clinical curative effect.