To discuss the effects of Yiqi Huoxue Fang combined with quadruple therapy on chronic atrophic gastritis (CAG) of helicobacter pylori (HP) positive stomach body in the type of spleen and stomach qi deficiency and blood stasis type diagnosed by Chinese medicine discrimination and its effects on pepsinogen (PG) and inflammatory factors.Methods:A total of 87 cases of Hp positive CAG admitted and treated in Tangshan Workers' Hospital from May 2013 to October 2016 were randomly divided into experimental group (n=45) and control group (n=42).The control group was treated with quadruple therapy,and the experimental group treated by Yiqi Huoxue Fang combined with quadruple therapy.PG test was performed before treatment (day 0) and after treatment (day 40) in the two groups.The clinical curative effect of the two groups and the changes of PG and inflammatory factors were compared.Results:After treatment,the effective rate of the experimental group was 84.44%,which was significantly higher than 64.29% of the control group (P<0.05).After treatment,PGⅠ content and PGⅠ/PGⅡ were significantly higher than those before treatment (P<0.05 or P<0.01),and the experimental group was significantly higher than the control group (P<0.05 or P<0.01); the contents of PGⅡ in two groups had not significantly changed compared with those before treatment (P>0.05),and there was no difference between the two groups (P>0.05); after treatment,IL-6,TNF-α and CRP of the two groups were significantly lower than those before treatment (P<0.01),and the experiment group was lower than the control group (P<0.01).Conclusion:Yiqi Huoxue Fang combined with quadruple therapy can improve the main clinical symptoms of Hp positive CAG patients,enhance the secretion of gastric mucosa,improve the content of PG in serum and reduce the level of inflammatory factors,which was safe and effective and worthy of clinical application.