| 引用本文:郑建彪，郑娜，王雯，黄静，赵娜，郝有志，张万辉.芪参还五胶囊联合羟乙基淀粉130/0.4对后循环缺血性眩晕患者心率、平均动脉压、氧分压的影响[J].世界中医药,2018,(02):. |
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| 芪参还五胶囊联合羟乙基淀粉130/0.4对后循环缺血性眩晕患者心率、平均动脉压、氧分压的影响 |
| Effects of Qishen Huanwu Capsules Combined with Hydroxyethyl Starch 130/0.4 on Heart Rate, Mean Arterial Pressure and Oxygen Partial Pressure for Patients with Posterior Circulation Ischemic Vertigo |
| 投稿时间：2017-04-13 |
| DOI：10.3969/j.issn.1673-7202.2018.02.021 |
| 中文关键词: 后循环缺血 眩晕 疗效 芪参还五胶囊 血流动力学 |
| English Keywords:Posterior circulation ischemia Vertigo Curative effect Qishen Huanwu Capsules Hemodynamics |
| 基金项目:河北省中医药管理局计划项目（20160121） |
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| 中文摘要: |
| 目的：探讨芪参还五胶囊联合羟乙基淀粉130/0.4对后循环缺血性眩晕（PCIV）患者心率（HR）、平均动脉压（MAP）、氧分压（PaO2）的影响。方法：选取2015年4月至2016年9月接受治疗的PCIV患者120例。按照随机数字表法均分为观察组和对照组，每组60例。对照组予以羟乙基淀粉130/0.4治疗，观察组则予以芪参还五胶囊联合羟乙基淀粉130/0.4治疗。分别比较2组疗效，治疗后HR、MAP、PaO2水平，治疗前后眩晕症状改善情况以及平均血流速度（VM）变化情况。结果：治疗后观察组总有效率为95.00%（57/60），高于对照组的81.67%（49/60）（P<0.05）。治疗后观察组HR、MAP、PaO2水平分别为（76.6±11.3）次/min、（91.2±10.4）mmHg、（81.4±12.6）mmHg，均高于对照组的（68.9±12.6）次/min、（81.7±11.5）mmHg、（73.2±12.8）mmHg，差异有统计学意义（P<0.05）。治疗后2组DHI评分均低于治疗前，而观察组又低于对照组，差异有统计学意义（P<0.05）。治疗后观察组左侧椎动脉VM、右侧椎动脉VM、基底动脉VM均高于对照组，差异有统计学意义（P<0.05）。结论：芪参还五胶囊联合羟乙基淀粉130/0.4治疗PCIV的疗效显著，且能有效维持患者生命体征稳定，减轻疾病对患者造成的影响，同时有效改善患者血流动学指标水平。 |
| English Summary: |
| To study the effects of Qishen Huanwu Capsules combined with hydroxyethyl starch 130/0.4 on heart rate (HR), mean arterial pressure (MAP) and oxygen partial pressure for patients with posterior circulation ischemic vertigo (PCIV). Methods:A total of 120 cases of patients with PCIV were admitted and treated in Cangzhou Hospital of Integrated Chinese and Western Medicine from April 2015 to September 2016. According to random number table method, patients were divided into observation group (60 cases) and control group (60 cases). Patients in control group were treated with hydroxyethyl starch 130/0.4 and patients in observation group were treated with Qishen Huanwu Capsules on the basis of that in control group. Curative effects of the two groups were respectively compared after treatment--heart rate (HR), mean arterial pressure (MAP), oxygen partial pressure (PaO2) levels, the improvement of vertigo symptom before and after treatment as well as the change of the mean flow velocity (VM). Results:The total effective rate of the treatment group was 95.00% (57/60), which was higher than that of control group 81.67% (49/60) (P<0.05). HR, MAP, PaO2 levels in observation group after treatment were respectively (76.6±11.3) times/min, (91.2±10.4) mmHg and (81.4±12.6) mmHg, which were higher than those in control group (68.9±12.6) times/min, (81.7±11.5) mmHg, (73.2±12.8) mmHg, and had significant difference (P<0.05). DHI scores after treatment in two groups were lower than those before the treatment and the observation group were lower than those in control group, which had significant differences (P<0.05). After treatment, the left side of the vertebral artery VM, the right side of the vertebral artery VM and the basal artery VM in treatment group were higher than those in control group, with significant differences (P<0.05). Conclusion:Qishen Huanwu Capsules combined with hydroxyethyl starch 130/0.4 had significant effects on PCIV and can effectively maintain stable vital signs, decrease the effects of disease of patients and effectively improve the patients' blood rheology indexes. |
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