To observe the clinical curative effect of traditional Chinese medicine fumigating eyes combined with thunder-fire moxibustion on the treatment of dry eye syndrome. Methods:A total of 120 dry eye patients (240 eyes) from outpatient department of Guangdong Second Traditional Chinese Medicine Hospital during March 2015 and August 2016 were randomly divided into four groups：artificial tears + Chinese herbal medicine fumigating eyes + thunder fire moxibustion (group A), the artificial tears control group (group B), artificial tears + Chinese herbal medicine fumigating eyes control group (group C), artificial tears + thunder fire moxibustion group (group D), with 30 cases in each group (60 eyes). Group A was treated with Chinese herbal medicine fumigating eyes once a day, thunder fire moxibustion fumigating eyes once a day, and Hypromellose Eye Drops dripping eyes four times a day. Group B received Hypromellose Eye Drops dripping eyes four times a day. Group C was treated with Chinese herbal medicine fumigating eyes once a day and Hypromellose Eye Drops dripping eyes four times a day; Group D received thunder fire moxibustion fumigating eyes once a day and Hypromellose Eye Drops dripping eyes four times a day. The course of treatment was 10 days. The clinical effect on each group, the four groups were observed before and after treatment about clinical symptom score, break-up time (BUT), Schirmer test (Schirmer test I), and corneal fluorescein staining (FL) were compared. Results:The total effective rate of Group A was 96.7%, 60.0% of group B, 80.0% of group C, and 83.3% of group D. There was significant difference between group A and B, C, D (P<0.05). There were also significant differences in clinical symptom score, BUT, Schirmer test I score and FL score between group A and B, C ,D (P<0.05). Conclusion:Artificial tears for the treatment of dry eye syndrome combined with Chinese herbal medicine fumigating eyes, thunder-fire moxibustion can obtain obvious therapeutic effect, which is worthy of clinical application and promotion.