| 引用本文:冯关周1，齐雪阳2，张勤生2.五味消毒饮配合布地奈德经鼻雾化吸入治疗鼻咽癌放疗后干燥性鼻咽炎的临床研究[J].世界中医药,2018,(02):. |
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| 五味消毒饮配合布地奈德经鼻雾化吸入治疗鼻咽癌放疗后干燥性鼻咽炎的临床研究 |
| Clinical Study on Wuwei Xiaodu Decoction Combined with Budesonide in the Treatment of Dry Pharyngitis after Radiotherapy of Nasopharyngeal Carcinoma by Nasal Inhalation |
| 投稿时间：2017-03-24 |
| DOI：10.3969/j.issn.1673-7202.2018.02.030 |
| 中文关键词: 五味消毒饮 布地奈德 鼻咽癌 干燥性鼻咽炎 炎性反应因子 免疫功能 |
| English Keywords:Wuwei Xiaodu Decoction Budesonide Nasopharyngeal carcinoma Dry pharyngitis Inflammatory factor Immunity |
| 基金项目:河南省科技厅科技攻关项目(112102310693) |
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| 中文摘要: |
| 目的：观察五味消毒饮配合布地奈德经鼻雾化吸入治疗鼻咽癌放疗后干燥性鼻咽炎的临床疗效，并探究对其炎性反应因子及免疫功能的影响。方法：选取2013年7月至2016年11月焦作市五官医院收治的鼻咽癌放疗后干燥性鼻咽炎患者126例，采用随机数字表法随机分为观察组和对照组，每组63例。对照组应用布地奈德经鼻雾化吸入治疗，观察组应用五味消毒饮配合布地奈德经鼻雾化吸入治疗，2组均连续治疗2周。评定2组治疗后临床疗效，检测2组治疗前后血清肿瘤坏死因子（TNF）-α、白细胞介素（IL）-2、IL-6和C反应蛋白（CRP）炎性反应因子水平，比较2组治疗前后CD3+、CD4+、CD8+、CD4+/CD8+和B淋巴细胞数免疫细胞亚群变化情况，记录2组治疗期间不良反应发生的情况。结果：治疗后，观察组临床治疗总有效率显著高于对照组，差异有统计学意义（P<0.05）；2组治疗后TNF-α、IL-6和CRP均较治疗前显著降低，差异有统计学意义（P<0.05）、IL-2较治疗前显著提高，差异有统计学意义（P<0.05），且观察组改善程度显著高于对照组，差异有统计学意义（P<0.05）；2组治疗后CD3+、CD4+和CD4+/CD8+均较治疗前显著提高，差异有统计学意义（P<0.05）、CD8+和B淋巴细胞数较治疗前显著降低，差异有统计学意义（P<0.05），且观察组改善程度显著高于对照组，差异有统计学意义（P<0.05）；2组治疗期间均未出现严重不良反应。结论：五味消毒饮配合布地奈德经鼻雾化吸入治疗鼻咽癌放疗后干燥性鼻咽炎，疗效显著，同时能改善炎性反应因子、增强免疫功能。 |
| English Summary: |
| To observe clinical effects of Wuwei Xiaodu Decoction combined with budesonide in treatment of dry pharyngitis after radiotherapy of nasopharyngeal carcinoma by nasal inhalation, and to explore the influence on inflammatory factors and immune function. Methods:A total of 126 cases of patients with dry pharyngitis after radiotherapy of nasopharyngeal carcinoma who were treated in Jiaozuo Otorhinolaryngology Hospital from July 2013 to November 2016 were divided into two groups randomly. The control group with 63 cases was given budesonide inhalation therapy, and the study group with 63 cases was given Wuwei Xiaodu Decoction combined with budesonide inhalation therapy, and both groups were treated for two weeks. Clinical effects were evaluated after treatment in the 2 groups, and Serum tumor necrosis factor (TNF)-α, Interleukin (IL)-2, IL-6 and C reactive protein (CRP) levels of inflammatory cytokines were examined before and after treatment in the 2 groups. Changes of CD3+, CD4+, CD8+, CD4+/CD8+ and B lymphocyte subsets in immune cells were compared before and after treatment, and adverse reaction was recorded during the treatment in the 2 groups. Results:After treatment, the total effective rate of the study group was significantly higher than that of the control group (P<0.05). After treatment, the levels of TNF-α, IL-6 and CRP were significantly lower than those before treatment in the 2 groups (P<0.05), and IL-2 was significantly higher than that before treatment (P<0.05). The improvement of the study group was significantly higher than that of the control group (P<0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ significantly increased (P<0.05), and CD8+ and B lymphocytes were significantly lower than those before treatment in the 2 groups (P<0.05). The improvement in the study group was significantly higher than that of control group (P<0.05). There were no serious adverse reactions during the treatment of the 2 groups. Conclusion:Wuwei Xiaodu Decoction combined with budesonide in the treatment of dry pharyngitis after radiotherapy of nasopharyngeal carcinoma by nasal inhalation has significant curative efficacy, which can improve inflammatory factors, and enhance immune function. |
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