To observe clinical effects of Wuwei Xiaodu Decoction combined with budesonide in treatment of dry pharyngitis after radiotherapy of nasopharyngeal carcinoma by nasal inhalation, and to explore the influence on inflammatory factors and immune function. Methods:A total of 126 cases of patients with dry pharyngitis after radiotherapy of nasopharyngeal carcinoma who were treated in Jiaozuo Otorhinolaryngology Hospital from July 2013 to November 2016 were divided into two groups randomly. The control group with 63 cases was given budesonide inhalation therapy, and the study group with 63 cases was given Wuwei Xiaodu Decoction combined with budesonide inhalation therapy, and both groups were treated for two weeks. Clinical effects were evaluated after treatment in the 2 groups, and Serum tumor necrosis factor (TNF)-α, Interleukin (IL)-2, IL-6 and C reactive protein (CRP) levels of inflammatory cytokines were examined before and after treatment in the 2 groups. Changes of CD3+, CD4+, CD8+, CD4+/CD8+ and B lymphocyte subsets in immune cells were compared before and after treatment, and adverse reaction was recorded during the treatment in the 2 groups. Results:After treatment, the total effective rate of the study group was significantly higher than that of the control group (P<0.05). After treatment, the levels of TNF-α, IL-6 and CRP were significantly lower than those before treatment in the 2 groups (P<0.05), and IL-2 was significantly higher than that before treatment (P<0.05). The improvement of the study group was significantly higher than that of the control group (P<0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ significantly increased (P<0.05), and CD8+ and B lymphocytes were significantly lower than those before treatment in the 2 groups (P<0.05). The improvement in the study group was significantly higher than that of control group (P<0.05). There were no serious adverse reactions during the treatment of the 2 groups. Conclusion:Wuwei Xiaodu Decoction combined with budesonide in the treatment of dry pharyngitis after radiotherapy of nasopharyngeal carcinoma by nasal inhalation has significant curative efficacy, which can improve inflammatory factors, and enhance immune function.